GI tract tumoursGene: STK11
As discussed in the GMS Inherited Cancer Specialist Test Group webex call 31st Jan 2019: The Specialist Test Group agreed that there is enough evidence to rate this gene green.
Created: 31 Jul 2019, 12:27 p.m. | Last Modified: 31 Jul 2019, 12:27 p.m.
Panel Version: 1.13
Variants in this GENE are reported as part of current diagnostic practice
Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Comment on phenotypes: Gastrointestinal and Colorectal Cancer High Risk
Created: 12 May 2017, 12:44 p.m.
Comment when marking as ready: Associated with phenotype in OMIM and as a confirmed G2P. At least 9 variants reported.
Created: 11 Apr 2017, 1:12 p.m.
Comment on phenotypes: Gastrointestinal and Colorectal Cancer risk. Also a confirmed DDG for Pancreatic cancer 260350
Created: 11 Apr 2017, 1:11 p.m.
Comment on list classification: Current diagnostic for Peutz-Jeghers which can present as bowel cancer.
Created: 7 Feb 2016, 9:29 p.m.
Mode of inheritance for this particular phenotype sourced from OMIM.
Created: 8 Jan 2016, 10:38 a.m.
Source Expert List was added to STK11. Source NHS GMS was added to STK11. Rating Changed from Green List (high evidence) to Green List (high evidence)
This panel has been formed as a result of merging Familial colon cancer (Version 1.5), Multiple bowel polyps (Version 1.9), Peutz-Jeghers syndrome (Version 0.20) panels and copying the reviews from each panel into this united GI Tract panel
Phenotypes for STK11 were set to Peutz-Jeghers syndrome 175200
Publications for STK11 were set to 20581245
STK11 was added to GI tractpanel. Source: Eligibility statement prior genetic testing STK11 was added to GI tractpanel. Source: Other
STK11 was added to GI tractpanel. Sources: Emory Genetics Laboratory,Expert Review Green
STK11 was created by ellenmcdonagh