GI tract tumours

Gene: STK11

Green List (high evidence)

STK11 (serine/threonine kinase 11)
EnsemblGeneIds (GRCh38): ENSG00000118046
EnsemblGeneIds (GRCh37): ENSG00000118046
OMIM: 602216, Gene2Phenotype
STK11 is in 14 panels

7 reviews

Ivone Leong (Genomics England Curator)

As discussed in the GMS Inherited Cancer Specialist Test Group webex call 31st Jan 2019: The Specialist Test Group agreed that there is enough evidence to rate this gene green.
Created: 31 Jul 2019, 12:27 p.m. | Last Modified: 31 Jul 2019, 12:27 p.m.
Panel Version: 1.13

Rachel Robinson (Leeds Genetics Laboratory)

Green List (high evidence)

Publications

Variants in this GENE are reported as part of current diagnostic practice

Lara Hawkes (Genomics England)

Green List (high evidence)

Ian Frayling (Cardiff University)

Green List (high evidence)

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Publications

  • Beggs, A. D., Latchford, A. R., Vasen, H. F. A., et al. Peutz–Jeghers syndrome: a systematic review and recommendations for management. Gut 2010
  • 59: 975-986.

Sarah Leigh (Genomics England Curator)

Comment on phenotypes: Gastrointestinal and Colorectal Cancer High Risk
Created: 12 May 2017, 12:44 p.m.
Comment when marking as ready: Associated with phenotype in OMIM and as a confirmed G2P. At least 9 variants reported.
Created: 11 Apr 2017, 1:12 p.m.
Comment on phenotypes: Gastrointestinal and Colorectal Cancer risk. Also a confirmed DDG for Pancreatic cancer 260350
Created: 11 Apr 2017, 1:11 p.m.

Ellen Thomas (Genomics England Curator)

Comment on list classification: Current diagnostic for Peutz-Jeghers which can present as bowel cancer.
Created: 7 Feb 2016, 9:29 p.m.

Ellen McDonagh (Genomics England Curator)

Mode of inheritance for this particular phenotype sourced from OMIM.
Created: 8 Jan 2016, 10:38 a.m.

History Filter Activity

29 Jan 2019, Gel status: 3

Added New Source, Added New Source, Status Update

Ivone Leong (Genomics England Curator)

Source Expert List was added to STK11. Source NHS GMS was added to STK11. Rating Changed from Green List (high evidence) to Green List (high evidence)

12 May 2017, Gel status: 4

panel promoted to version 1

Sarah Leigh (Genomics England Curator)

This panel has been formed as a result of merging Familial colon cancer (Version 1.5), Multiple bowel polyps (Version 1.9), Peutz-Jeghers syndrome (Version 0.20) panels and copying the reviews from each panel into this united GI Tract panel

12 May 2017, Gel status: 4

Set Phenotypes

Sarah Leigh (Genomics England Curator)

Phenotypes for STK11 were set to Peutz-Jeghers syndrome 175200

12 May 2017, Gel status: 4

Set publications

Sarah Leigh (Genomics England Curator)

Publications for STK11 were set to 20581245

11 May 2017, Gel status: 4

Added New Source

Ellen McDonagh (Genomics England Curator)

STK11 was added to GI tractpanel. Source: Eligibility statement prior genetic testing STK11 was added to GI tractpanel. Source: Other

11 May 2017, Gel status: 4

Added New Source

Ellen McDonagh (Genomics England Curator)

STK11 was added to GI tractpanel. Sources: Emory Genetics Laboratory,Expert Review Green

11 May 2017, Gel status: 0

Created

Ellen McDonagh (Genomics England Curator)

STK11 was created by ellenmcdonagh