GI tract tumours
Gene: FOXO3

FOXO3 (forkhead box O3)
EnsemblGeneIds (GRCh38): ENSG00000118689
EnsemblGeneIds (GRCh37): ENSG00000118689
OMIM: 602681, Gene2Phenotype
FOXO3 is in 1 panel

1 review

Sarah Leigh (Genomics England Curator)

Red List (low evidence)

rs2802292 SNP identifies FOXO3A as a modifier locus predicting cancer risk in patients with PJS and PHTS hamartomatous polyposis syndromes.
Created: 13 Apr 2017, 9:56 a.m.

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Phenotypes
Hamartomatous polyposis syndromes including Peutz-Jeghers and PTEN hamartoma tumor syndromes

Publications

25208626

Created: 13 Apr 2017, 9:56 a.m.

Panel version: Imported from "Peutz-Jeghers syndrome" panel version 0.17

Details

Mode of Inheritance

MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Sources

Literature

Phenotypes

Hamartomatous polyposis syndromes including Peutz-Jeghers and PTEN hamartoma tumor syndromes

OMIM

602681

Clinvar variants

Variants in FOXO3

Penetrance

Complete

Publications

25208626

Panels with this gene

GI tract tumours

History Filter Activity

12 May 2017, Gel status: 0

panel promoted to version 1

Sarah Leigh (Genomics England Curator)

This panel has been formed as a result of merging Familial colon cancer (Version 1.5), Multiple bowel polyps (Version 1.9), Peutz-Jeghers syndrome (Version 0.20) panels and copying the reviews from each panel into this united GI Tract panel

11 May 2017, Gel status: 0

Added New Source

Ellen McDonagh (Genomics England Curator)

FOXO3 was added to GI tractpanel. Sources: Literature