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  3. MSH3
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GI tract tumours

Gene: MSH3

Red List (low evidence)
MSH3 (mutS homolog 3)
EnsemblGeneIds (GRCh38): ENSG00000113318
EnsemblGeneIds (GRCh37): ENSG00000113318
OMIM: 600887, Gene2Phenotype
MSH3 is in 2 panels

2 reviews

Rachel Robinson (Leeds Genetics Laboratory)

Green List (high evidence)

Publications

Created: 29 Jan 2019, 4:47 p.m.

Panel version: 1.10

Treena Cranston (Oxford)

Red List (low evidence)

Discussed with Prof Ian Tomlinson. To be added to PanelApp as there has been a recent proposal that it may be asssociated with autosomal recessive polyposis/CRC. Not yet published hence low evidence.
Created: 20 Jul 2016, 7:09 a.m.

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Created: 20 Jul 2016, 7:09 a.m.

Panel version: Imported from "Familial colon cancer" panel version 1.2

Details

Mode of Inheritance
BIALLELIC, autosomal or pseudoautosomal
Sources
  • NHS GMS
  • Research
  • Expert Review Red
OMIM
600887
Clinvar variants
Variants in MSH3
Penetrance
Complete
Panels with this gene

History Filter Activity

29 Jan 2019, Gel status: 1

Added New Source

Ivone Leong (Genomics England Curator)

Source NHS GMS was added to MSH3.

12 May 2017, Gel status: 1

panel promoted to version 1

Sarah Leigh (Genomics England Curator)

This panel has been formed as a result of merging Familial colon cancer (Version 1.5), Multiple bowel polyps (Version 1.9), Peutz-Jeghers syndrome (Version 0.20) panels and copying the reviews from each panel into this united GI Tract panel

11 May 2017, Gel status: 1

Added New Source

Ellen McDonagh (Genomics England Curator)

MSH3 was added to GI tractpanel. Sources: Research,Expert Review Red

11 May 2017, Gel status: 0

Created

Ellen McDonagh (Genomics England Curator)

MSH3 was created by ellenmcdonagh