Multiple Tumours
Gene: MET

MET (MET proto-oncogene, receptor tyrosine kinase)
EnsemblGeneIds (GRCh38): ENSG00000105976
EnsemblGeneIds (GRCh37): ENSG00000105976
OMIM: 164860, Gene2Phenotype
MET is in 10 panels

1 review

Ellen McDonagh (Genomics England Curator)

Comment on list classification: Promoted from red to green, as this gene is reported as part of germline findings in the Cancer Programme, for Renal cancer.
Created: 18 Apr 2017, 9:41 a.m.

Comment on mode of pathogenicity: Activating variants in this gene are causative, loss-of-function variants are not reported.
Created: 18 Apr 2017, 9:41 a.m.

Information from TruSight panel: Pathogenic Mutations are Activating.
Created: 5 Feb 2016, 11:46 a.m.

Mode of pathogenicity
Other - please provide details in the comments

Created: 5 Feb 2016, 11:46 a.m.

Panel version: 0.2

Details

Mode of Inheritance

MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Sources

Expert Review Green
TruSight Cancer Panel (Illumina)

Phenotypes

Renal cell cancer (papillary carcinoma)

OMIM

164860

Clinvar variants

Variants in MET

Penetrance

Complete

Mode of Pathogenicity

Loss-of-function variants (as defined in pop up message) DO NOT cause this phenotype - please provide details in the comments

Panels with this gene