Multiple endocrine tumours
Gene: RETEnsemblGeneIds (GRCh38): ENSG00000165731
EnsemblGeneIds (GRCh37): ENSG00000165731
OMIM: 164761, Gene2Phenotype
RET is in 30 panels
4 reviews
Katie Snape (South London GMC)
Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Variants in this GENE are reported as part of current diagnostic practice
Treena Cranston (Oxford)
Sian Ellard (University of Exeter Medical School)
Louise IZATT (GSTT Clinical Genetics Service)
Variants in this gene are already reported as part of UKGTN diagnostic service, but GeL will offer WGS analysis.Created: 16 Oct 2015, 12:53 p.m.
Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Details
- Mode of Inheritance
- MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
- Sources
-
- Expert Review Green
- Eligibility statement prior genetic testing
- Expert list
- UKGTN
- Radboud University Medical Center, Nijmegen
- Illumina TruGenome Clinical Sequencing Services
- Emory Genetics Laboratory
- Phenotypes
-
- Multiple endocrine neoplasia IIA, 171400
- Multiple Endocrine Neoplasia
- Multiple Endocrine Neoplasia Type 2: RET Gene Deletion/Duplication
- MEN2-like spectrum
- Endocrine Cancer
- OMIM
- 164761
- Clinvar variants
- Variants in RET
- Penetrance
- Complete
- Panels with this gene
-
- Primary immunodeficiency or monogenic inflammatory bowel disease
- Familial pulmonary fibrosis
- Gastrointestinal neuromuscular disorders
- Familial hyperparathyroidism or hypocalciuric hypercalcaemia
- COVID-19 research
- Multiple endocrine tumours
- Inherited phaeochromocytoma and paraganglioma excluding NF1
- Fetal anomalies
- Thyroid cancer pertinent cancer susceptibility
- Gastrointestinal epithelial barrier disorders
- Childhood solid tumours cancer susceptibility
- Sudden death in young people
- Inherited phaeochromocytoma and paraganglioma
- Unexplained kidney failure in young people
- Additional findings health related - children
- DDG2P
- Parathyroid Cancer
- Intellectual disability
- Paediatric pseudo-obstruction syndrome
- Familial Hirschsprung Disease
- Hirschsprung disease
- Adult solid tumours for rare disease
- Unexplained young onset end-stage renal disease - additional genes
- Childhood solid tumours
- Adult solid tumours cancer susceptibility
- Endocrine neoplasia
- Additional findings health related
- Neuroendocrine cancer pertinent cancer susceptibility
- Multiple endocrine neoplasia type 2
- CAKUT
History Filter Activity
Gene classified by Genomics England curator
Ellen McDonagh (Genomics England Curator)This gene has been classified as Green List (High Evidence).
Set Mode of Inheritance
Ellen McDonagh (Genomics England Curator)Mode of inheritance for RET was changed to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Set Phenotypes
Eik Haraldsdottir (Genomics England)Phenotypes for gene RET were set to Multiple endocrine neoplasia IIA, 171400;Multiple Endocrine Neoplasia;Multiple Endocrine Neoplasia Type 2: RET Gene Deletion/Duplication;MEN2-like spectrum; Endocrine Cancer
Added New Source
Ellen McDonagh (Genomics England Curator)RET was added to Multiple endocrine tumourspanel. Sources: Eligibility statement prior genetic testing
Added New Source
Eik Haraldsdottir (Genomics England)RET was added to Multiple endocrine tumourspanel. Sources: Eligibility Statements for GeL,Expert list
Added New Source
Eik Haraldsdottir (Genomics England)RET was added to Multiple endocrine tumourspanel. Sources: Eligibility Statements for GeL,Expert list
Added New Source
Eik Haraldsdottir (Genomics England)RET was added to Multiple endocrine tumourspanel. Sources: Emory Genetics Laboratory,Illumina TruGenome Clinical Sequencing Services,Radboud University Medical Center, Nijmegen,UKGTN
Added New Source
Eik Haraldsdottir (Genomics England)RET was added to Multiple endocrine tumourspanel. Sources: Emory Genetics Laboratory,Illumina TruGenome Clinical Sequencing Services,Radboud University Medical Center, Nijmegen,UKGTN
Added New Source
Eik Haraldsdottir (Genomics England)RET was added to Multiple endocrine tumourspanel. Sources: Emory Genetics Laboratory,Illumina TruGenome Clinical Sequencing Services,Radboud University Medical Center, Nijmegen,UKGTN
Added New Source
Eik Haraldsdottir (Genomics England)RET was added to Multiple endocrine tumourspanel. Sources: Emory Genetics Laboratory,Illumina TruGenome Clinical Sequencing Services,Radboud University Medical Center, Nijmegen,UKGTN