Likely inborn error of metabolism
Gene: FMO3

FMO3 (flavin containing monooxygenase 3)
EnsemblGeneIds (GRCh38): ENSG00000007933
EnsemblGeneIds (GRCh37): ENSG00000007933
OMIM: 136132, Gene2Phenotype
FMO3 is in 4 panels

1 review

Sarah Leigh (Genomics England Curator)

Green List (high evidence)

at least 14 variants identified
Created: 23 Feb 2017, 5:13 p.m.

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Phenotypes
Trimethylaminuria (Disorders and variants of enzymes that oxidise xenobiotics other than cytochrome P450)

Publications

27604308

Created: 23 Feb 2017, 5:13 p.m.

Panel version: Imported from Undiagnosed metabolic disorders panel version 0.304

Details

Mode of Inheritance

BIALLELIC, autosomal or pseudoautosomal

Sources

London North GLH
NHS GMS
Expert Review Green

Phenotypes

Trimethylaminuria (Disorders and variants of enzymes that oxidise xenobiotics other than cytochrome P450)

OMIM

136132

Clinvar variants

Variants in FMO3

Penetrance

None

Publications

27604308

Panels with this gene

History Filter Activity

13 Feb 2019, Gel status: 4

Added New Source, Added New Source

Ivone Leong (Genomics England Curator)

Source NHS GMS was added to FMO3. Source London North GLH was added to FMO3.

8 Jan 2019, Gel status: 4

Panel promoted to version 1.0

Ellen McDonagh (Genomics England Curator)

Checked against super panel made up of the panel constituents. Ready to promote to version 1.

16 Dec 2018, Gel status: 4

Created, Added New Source, Set mode of inheritance, Set publications, Set Phenotypes