1. Panels
  2. Research panel - Severe Paediatric Disorders
  3. GLI3
Genes in panel
Prev Next
STRs in panel
Prev Next
Regions in panel
Prev Next

Research panel - Severe Paediatric Disorders

Gene: GLI3

Green List (high evidence)
GLI3 (GLI family zinc finger 3)
EnsemblGeneIds (GRCh38): ENSG00000106571
EnsemblGeneIds (GRCh37): ENSG00000106571
OMIM: 165240, Gene2Phenotype
GLI3 is in 25 panels

1 review

Louise Daugherty (Genomics England Curator)

I don't know

Initial gene list (NGC_genelist-20190823_GREEN_dis_moi_forCuration_20200211.xlsx) collated by Dr Courtney French (University of Cambridge University Hospital NHS Foundation), Dr Karyn Megy (Clinical Feedback Lead, NIHR BioResource - Rare Diseases Study, University of Cambridge University Hospital NHS Foundation), Dr Alba Sanchis-Juan (NIHR BioResource - Rare Diseases Study, University of Cambridge University Hospital NHS Foundation) and Lucy Raymond (Professor of Medical Genetics and Neurodevelopment, University of Cambridge University Hospital NHS Foundation). Submitted to the PanelApp resource January 2020 on behalf of the Next Generation Children Project, Addenbrookes' Hospital, Cambridge. Gene Symbol submitted: GLI3; Recommended initial gene rating: Green List (high evidence); Phenotypes: Greig cephalopolysyndactyly syndrome, 175700 (3) | Pallister-Hall syndrome, 146510 (3) | Polydactyly, postaxial, types A1 and B, 174200 (3) | Polydactyly, preaxial, type IV, 174700 (3); Mode of inheritance: Autosomal dominant | Autosomal dominant | Autosomal dominant | Autosomal dominant
Created: 20 Feb 2020, 5:19 p.m. | Last Modified: 20 Feb 2020, 5:19 p.m.
Panel Version: 0.12
Created: 20 Feb 2020, 5:19 p.m.
Last Modified: 20 Feb 2020, 5:19 p.m.
Panel version: 0.12

History Filter Activity

21 Feb 2020, Gel status: 3

Set mode of inheritance

Louise Daugherty (Genomics England Curator)

Mode of inheritance for gene GLI3 was changed from to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

20 Feb 2020, Gel status: 3

Set publications

Louise Daugherty (Genomics England Curator)

Publications for gene GLI3 were updated from to 30847515

20 Feb 2020, Gel status: 3

Set Phenotypes

Louise Daugherty (Genomics England Curator)

Added phenotypes Pallister-Hall syndrome, 146510; Greig cephalopolysyndactyly syndrome, 175700; Polydactyly, preaxial, type IV, 174700; Polydactyly, postaxial, types A1 and B, 174200 for gene: GLI3

20 Feb 2020, Gel status: 3

Set Phenotypes

Louise Daugherty (Genomics England Curator)

Added phenotypes Pallister-Hall syndrome, 146510; Greig cephalopolysyndactyly syndrome, 175700; Polydactyly, preaxial, type IV, 174700; Polydactyly, postaxial, types A1 and B, 174200 for gene: GLI3

20 Feb 2020, Gel status: 3

Set Phenotypes

Louise Daugherty (Genomics England Curator)

Added phenotypes Pallister-Hall syndrome, 146510; Greig cephalopolysyndactyly syndrome, 175700; Polydactyly, preaxial, type IV, 174700; Polydactyly, postaxial, types A1 and B, 174200 for gene: GLI3

19 Feb 2020, Gel status: 3

Set Phenotypes

Louise Daugherty (Genomics England Curator)

Added phenotypes Greig cephalopolysyndactyly syndrome, 175700; Pallister-Hall syndrome, 146510; Polydactyly, preaxial, type IV, 174700; Polydactyly, postaxial, types A1 and B, 174200 for gene: GLI3

14 Feb 2020, Gel status: 3

Added New Source

Louise Daugherty (Genomics England Curator)

Source Next Generation Children Project was added to GLI3.

14 Feb 2020, Gel status: 3

Added New Source, Status Update

Louise Daugherty (Genomics England Curator)

Source Expert Review Green was added to GLI3. Rating Changed from Red List (low evidence) to Green List (high evidence)

14 Feb 2020, Gel status: 1

Created, Added New Source, Set mode of inheritance

Louise Daugherty (Genomics England Curator)

gene: GLI3 was added gene: GLI3 was added to Severe Paediatric Disorders. Sources: Expert list Mode of inheritance for gene: GLI3 was set to