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Severe Paediatric Disorders

Gene: IL17A

Red List (low evidence)

IL17A (interleukin 17A)
EnsemblGeneIds (GRCh38): ENSG00000112115
EnsemblGeneIds (GRCh37): ENSG00000112115
OMIM: 603149, Gene2Phenotype
IL17A is in 3 panels

1 review

Louise Daugherty (Genomics England Curator)

I don't know

Initial gene list (NGC_genelist-20190823_GREEN_dis_moi_forCuration_20200211.xlsx) collated by Dr Courtney French (University of Cambridge University Hospital NHS Foundation), Dr Karyn Megy (Clinical Feedback Lead, NIHR BioResource - Rare Diseases Study, University of Cambridge University Hospital NHS Foundation), Dr Alba Sanchis-Juan (NIHR BioResource - Rare Diseases Study, University of Cambridge University Hospital NHS Foundation) and Lucy Raymond (Professor of Medical Genetics and Neurodevelopment, University of Cambridge University Hospital NHS Foundation). Submitted to the PanelApp resource January 2020 on behalf of the Next Generation Children Project, Addenbrookes' Hospital, Cambridge. Gene Symbol submitted: IL17A; Recommended initial gene rating: Red List (low evidence); Phenotypes: {Graft-versus-host disease, protection against}, 614395 (3) | {HIV-1, susceptibility to}, 609423 (3) | {Rheumatoid arthritis, progression of}, 180300 (3); Mode of inheritance: ND | ND | ND
Created: 20 Feb 2020, 5:28 p.m. | Last Modified: 20 Feb 2020, 5:28 p.m.
Panel Version: 0.12

Details

Mode of Inheritance
Unknown
Sources
  • Next Generation Children Project
  • Expert Review Red
  • Expert list
Phenotypes
  • {HIV-1, susceptibility to}, 609423
  • {Graft-versus-host disease, protection against}, 614395
  • {Rheumatoid arthritis, progression of}, 180300
OMIM
603149
Clinvar variants
Variants in IL17A
Penetrance
None
Publications
Panels with this gene

History Filter Activity

20 Feb 2020, Gel status: 1

Set publications

Louise Daugherty (Genomics England Curator)

Publications for gene IL17A were updated from to 30847515

20 Feb 2020, Gel status: 1

Set Phenotypes

Louise Daugherty (Genomics England Curator)

Added phenotypes {HIV-1, susceptibility to}, 609423; {Graft-versus-host disease, protection again