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Severe Paediatric Disorders

Gene: FGG

Green List (high evidence)

FGG (fibrinogen gamma chain)
EnsemblGeneIds (GRCh38): ENSG00000171557
EnsemblGeneIds (GRCh37): ENSG00000171557
OMIM: 134850, Gene2Phenotype
FGG is in 4 panels

1 review

Louise Daugherty (Genomics England Curator)

I don't know

Initial gene list (NGC_genelist-20190823_GREEN_dis_moi_forCuration_20200211.xlsx) collated by Dr Courtney French (University of Cambridge University Hospital NHS Foundation), Dr Karyn Megy (Clinical Feedback Lead, NIHR BioResource - Rare Diseases Study, University of Cambridge University Hospital NHS Foundation), Dr Alba Sanchis-Juan (NIHR BioResource - Rare Diseases Study, University of Cambridge University Hospital NHS Foundation) and Lucy Raymond (Professor of Medical Genetics and Neurodevelopment, University of Cambridge University Hospital NHS Foundation). Submitted to the PanelApp resource January 2020 on behalf of the Next Generation Children Project, Addenbrookes' Hospital, Cambridge. Gene Symbol submitted: FGG; Recommended initial gene rating: Green List (high evidence); Phenotypes: Afibrinogenemia, congenital, 202400 (3) | Dysfibrinogenemia, congenital, 616004 (3) | Hypodysfibrinogenemia, 616004 (3) | Hypofibrinogenemia, congenital, 202400 (3); Mode of inheritance: Autosomal recessive | ND | ND | Autosomal recessive
Created: 20 Feb 2020, 5:19 p.m. | Last Modified: 20 Feb 2020, 5:19 p.m.
Panel Version: 0.12

Details

Mode of Inheritance
BOTH monoallelic and biallelic, autosomal or pseudoautosomal
Sources
  • Next Generation Children Project
  • Expert Review Green
  • Expert list
Phenotypes
  • Dysfibrinogenemia, congenital, 616004
  • Hypodysfibrinogenemia, 616004
  • Afibrinogenemia, congenital, 202400
  • Hypofibrinogenemia, congenital, 202400
OMIM
134850
Clinvar variants
Variants in FGG
Penetrance
None
Publications
Panels with this gene

History Filter Activity

21 Feb 2020, Gel status: 3

Set mode of inheritance

Louise Daugherty (Genomics England Curator)

Mode of inheritance for gene FGG was changed from to BOTH monoallelic and biallelic, autosomal or pseudoautosomal

20 Feb 2020, Ge