Research panel - Severe Paediatric Disorders
Gene: WT1

WT1 (Wilms tumor 1)
EnsemblGeneIds (GRCh38): ENSG00000184937
EnsemblGeneIds (GRCh37): ENSG00000184937
OMIM: 607102, Gene2Phenotype
WT1 is in 19 panels

1 review

Louise Daugherty (Genomics England Curator)

I don't know

Initial gene list (NGC_genelist-20190823_GREEN_dis_moi_forCuration_20200211.xlsx) collated by Dr Courtney French (University of Cambridge University Hospital NHS Foundation), Dr Karyn Megy (Clinical Feedback Lead, NIHR BioResource - Rare Diseases Study, University of Cambridge University Hospital NHS Foundation), Dr Alba Sanchis-Juan (NIHR BioResource - Rare Diseases Study, University of Cambridge University Hospital NHS Foundation) and Lucy Raymond (Professor of Medical Genetics and Neurodevelopment, University of Cambridge University Hospital NHS Foundation). Submitted to the PanelApp resource January 2020 on behalf of the Next Generation Children Project, Addenbrookes' Hospital, Cambridge. Gene Symbol submitted: WT1; Recommended initial gene rating: Green List (high evidence); Phenotypes: Denys-Drash syndrome, 194080 (3) | Frasier syndrome, 136680 (3) | Meacham syndrome, 608978 (3) | Nephrotic syndrome, type 4, 256370 (3) | Wilms tumor, type 1, 194070 (3); Mode of inheritance: Autosomal dominant, Somatic mutation | Autosomal dominant, Somatic mutation | ND | Autosomal dominant | Autosomal dominant, Somatic mutation
Created: 20 Feb 2020, 5:27 p.m. | Last Modified: 20 Feb 2020, 5:27 p.m.

Panel Version: 0.12

Created: 20 Feb 2020, 5:27 p.m.
Last Modified: 20 Feb 2020, 5:27 p.m.
Panel version: 0.12

Details

Mode of Inheritance

MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Sources

Next Generation Children Project
Expert Review Green
Expert list

Phenotypes

Wilms tumor, type 1, 194070
Denys-Drash syndrome, 194080
Frasier syndrome, 136680
Meacham syndrome, 608978
Nephrotic syndrome, type 4, 256370

OMIM

607102

Clinvar variants

Variants in WT1

Penetrance

None

Publications

30847515

Panels with this gene