Genes in panel
STRs in panel
Prev Next
Regions in panel
Prev Next

Severe Paediatric Disorders

Gene: WT1

Green List (high evidence)

WT1 (Wilms tumor 1)
EnsemblGeneIds (GRCh38): ENSG00000184937
EnsemblGeneIds (GRCh37): ENSG00000184937
OMIM: 607102, Gene2Phenotype
WT1 is in 22 panels

1 review

Louise Daugherty (Genomics England Curator)

I don't know

Initial gene list (NGC_genelist-20190823_GREEN_dis_moi_forCuration_20200211.xlsx) collated by Dr Courtney French (University of Cambridge University Hospital NHS Foundation), Dr Karyn Megy (Clinical Feedback Lead, NIHR BioResource - Rare Diseases Study, University of Cambridge University Hospital NHS Foundation), Dr Alba Sanchis-Juan (NIHR BioResource - Rare Diseases Study, University of Cambridge University Hospital NHS Foundation) and Lucy Raymond (Professor of Medical Genetics and Neurodevelopment, University of Cambridge University Hospital NHS Foundation). Submitted to the PanelApp resource January 2020 on behalf of the Next Generation Children Project, Addenbrookes' Hospital, Cambridge. Gene Symbol submitted: WT1; Recommended initial gene rating: Green List (high evidence); Phenotypes: Denys-Drash syndrome, 194080 (3) | Frasier syndrome, 136680 (3) | Meacham syndrome, 608978 (3) | Nephrotic syndrome, type 4, 256370 (3) | Wilms tumor, type 1, 194070 (3); Mode of inheritance: Autosomal dominant, Somatic mutation | Autosomal dominant, Somatic mutation | ND | Autosomal dominant | Autosomal dominant, Somatic mutation
Created: 20 Feb 2020, 5:27 p.m. | Last Modified: 20 Feb 2020, 5:27 p.m.
Panel Version: 0.12

Details

Mode of Inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Sources
  • Next Generation Children Project
  • Expert Review Green
  • Expert list
Phenotypes
  • Wilms tumor, type 1, 194070
  • Denys-Drash syndrome, 194080
  • Frasier syndrome, 136680
  • Meacham syndrome, 608978
  • Nephrotic syndrome, type 4, 256370
OMIM
607102
Clinvar variants
Variants in WT1
Penetrance
None
Publications
Panels with this gene