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Viral resistance

Gene: CXCR1

Green List (high evidence)
CXCR1 (C-X-C motif chemokine receptor 1)
EnsemblGeneIds (GRCh38): ENSG00000163464
EnsemblGeneIds (GRCh37): ENSG00000163464
OMIM: 146929, Gene2Phenotype
CXCR1 is in 0 panels

1 review

Ivone Leong (Genomics England Curator)

Comment on list classification: PMID: 17360650 found a CXCR1 haplotype made up of 2 SNPs (rs16858811) that caused M31R change in the N-terminal extracellular domain, and rs1658808 caused R335C in the C-terminal intracellular domain. The frequency of this haplotype was significantly lower in 84 French HIV-1-infected patients who progressed rapidly to AIDS compared with 253 French HIV-1-infected patients who progressed slowly to AIDS. The authors concluded that the CXCR1 haplotype protects against rapid progression of HIV-1 infected patients to AIDS.

PMID: 25121556 showed the mechanism of how the CXCR1 haplotype affects AIDS progression.
Created: 4 May 2020, 1:24 p.m. | Last Modified: 4 May 2020, 1:24 p.m.
Panel Version: 0.32
Created: 4 May 2020, 1:24 p.m.
Last Modified: 4 May 2020, 1:24 p.m.
Panel version: 0.32

Details

Mode of Inheritance
Unknown
Sources
  • Expert Review Green
  • OMIM
Phenotypes
  • {AIDS, slow progression to} 609423
OMIM
146929
Clinvar variants
Variants in CXCR1
Penetrance
None
Publications
Panels with this gene

History Filter Activity

14 May 2020, Gel status: 3

Entity classified by Genomics England curator

Ivone Leong (Genomics England Curator)

Gene: cxcr1 has been classified as Green List (High Evidence).

14 May 2020, Gel status: 2

Set mode of inheritance

Ivone Leong (Genomics England Curator)

Mode of inheritance for gene: CXCR1 was changed from to Unknown

4 May 2020, Gel status: 2

Entity classified by Genomics England curator

Ivone Leong (Genomics England Curator)

Gene: cxcr1 has been classified as Amber List (Moderate Evidence).

4 May 2020, Gel status: 1

Set publications

Ivone Leong (Genomics England Curator)

Publications for gene: CXCR1 were set to 17360650

28 Apr 2020, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set publications, Set Phenotypes

Sarah Leigh (Genomics England Curator)

gene: CXCR1 was added gene: CXCR1 was added to Viral resistance. Sources: OMIM Mode of inheritance for gene: CXCR1 was set to Publications for gene: CXCR1 were set to 17360650 Phenotypes for gene: CXCR1 were set to {AIDS, slow progression to} 609423