Viral resistance
Gene: HLA-B

HLA-B (major histocompatibility complex, class I, B)
EnsemblGeneIds (GRCh38): ENSG00000234745
EnsemblGeneIds (GRCh37): ENSG00000234745
OMIM: 142830, Gene2Phenotype
HLA-B is in 3 panels

1 review

Rebecca Foulger (Genomics England curator)

PMID:32303592 (Nguyen et al., 2020) performed in-silico analysis of viral-binding affinity across HLA genotypes for SARS-CoV-2 peptides. Based on in-silico results, they suggest that individuals with HLA-B*46:01 may be vulnerable to COVID-19. Conversely, HLA-B*15:03 may enable greater immunity.
Sources: Literature
Created: 23 Apr 2020, 1:41 p.m.

Mode of inheritance
Unknown

Phenotypes
immunity to COVID-19

Publications

32303592

Created: 23 Apr 2020, 1:41 p.m.

Panel version: 0.8

Details

Mode of Inheritance

Unknown

Sources

Literature

Phenotypes

immunity to COVID-19

OMIM

142830

Clinvar variants

Variants in HLA-B

Penetrance

None

Publications

32303592

Panels with this gene

History Filter Activity

23 Apr 2020, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set publications, Set Phenotypes

Rebecca Foulger (Genomics England curator)

gene: HLA-B was added gene: HLA-B was added to Viral resistance. Sources: Literature Mode of inheritance for gene: HLA-B was set to Unknown Publications for gene: HLA-B were set to 32303592 Phenotypes for gene: HLA-B were set to immunity to COVID-19

Viral resistance Gene: HLA-B