Viral resistance

Gene: MX1

Comment on list classification: PMID: 30696001 fused a cell penetrating peptide to the C-terminus of the Mx1 protein and found that it inhibited viral replication and viral RNA expression in infected cells. Administration of this fused protein improved the survival of mice infected with PR8 influenza viral strain. The paper suggests that this fused protein could be used as a therapeutic agent.

Created: 14 May 2020, 10:30 a.m. | Last Modified: 14 May 2020, 10:30 a.m.

Panel Version: 0.48

I don't know

MX1 is an interferon-induced protein with antiviral activity (PMID 3162334).
PMID 14872030 c.-88G>T was more frequent in 40 unrelated Japanese patients with subacute sclerosing panencephalitisis (associated with CNS infection with measles virus), than in 90 controls (0.42 in patients vs 0.29 in controls). Variant c.-88G>T results increased MX1 expression, the authors suggest that MX1 may paradoxically enable persistence of the virus in the CNS by attenuating viral gene expression and preventing complete immunologic clearance.
PMID 21935451 concluded that genetic variation in the interferon response pathway is associated with risk for symptomatic West Nile viru infection and disease progression.
Preprint https://doi.org/10.1101/2020.05.04.075911 Reports that rs35074065 of TMPRSS2 results in increased expression of the nearby gene MX1.
Sources: Literature

Created: 12 May 2020, 10:59 a.m.

Mode of inheritance
Unknown

Publications

• 3162334
• 14872030
• 21935451
• https://doi.org/10.1101/2020.05.04.07591