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Viral resistance

Gene: TNF

Green List (high evidence)
TNF (tumor necrosis factor)
EnsemblGeneIds (GRCh38): ENSG00000232810
EnsemblGeneIds (GRCh37): ENSG00000232810
OMIM: 191160, Gene2Phenotype
TNF is in 3 panels

2 reviews

Ivone Leong (Genomics England Curator)

Comment on list classification: Based on the following evidece there is enough evidence to make this gene Green.
Created: 14 May 2020, 10:01 a.m. | Last Modified: 14 May 2020, 10:01 a.m.
Panel Version: 0.47
Comment on publications: PMID: 25047809, 25661729 are two papers describing mouse models where blocking TNFa impairs HBV clearance.

PMID: 24077913, 19447932, 25447852 describe how anti-TNFa treatments increase the risk of HBV reactivation in patients who have chronic HBV infection.
Created: 14 May 2020, 10:01 a.m. | Last Modified: 14 May 2020, 10:01 a.m.
Panel Version: 0.46
Created: 14 May 2020, 10:01 a.m.
Last Modified: 14 May 2020, 10:01 a.m.
Panel version: 0.46

Sarah Leigh (Genomics England Curator)

Haplotypes of TNF promoter polymorphisms are associated with clearance of hepatitis B virus infection in Korean subjects (PMID 12915457).
Created: 4 May 2020, 3:56 p.m. | Last Modified: 4 May 2020, 3:56 p.m.
Panel Version: 0.34
Created: 4 May 2020, 3:56 p.m.
Last Modified: 4 May 2020, 3:56 p.m.
Panel version: 0.34

Details

Mode of Inheritance
Unknown
Sources
  • Expert Review Green
  • OMIM
OMIM
191160
Clinvar variants
Variants in TNF
Penetrance
None
Publications
Panels with this gene

History Filter Activity

14 May 2020, Gel status: 3

Entity classified by Genomics England curator

Ivone Leong (Genomics England Curator)

Gene: tnf has been classified as Green List (High Evidence).

14 May 2020, Gel status: 1

Set publications

Ivone Leong (Genomics England Curator)

Publications for gene: TNF were set to 12915457

14 May 2020, Gel status: 1

Set mode of inheritance

Ivone Leong (Genomics England Curator)

Mode of inheritance for gene: TNF was changed from to Unknown

4 May 2020, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set publications

Sarah Leigh (Genomics England Curator)

gene: TNF was added gene: TNF was added to Viral resistance. Sources: OMIM Mode of inheritance for gene: TNF was set to Publications for gene: TNF were set to 12915457