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  3. WT1
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Cytopenias and congenital anaemias

Gene: WT1

Red List (low evidence)
WT1 (Wilms tumor 1)
EnsemblGeneIds (GRCh38): ENSG00000184937
EnsemblGeneIds (GRCh37): ENSG00000184937
OMIM: 607102, Gene2Phenotype
WT1 is in 18 panels

2 reviews

Sarah Leigh (Genomics England Curator)

Comment when marking as ready: Somatic variants responsible for acute myeloid leukaemia (20368469, 27252512, 8630376). Germline and somatic variants associated with other phenotypes (see comments), not relevant to this panel
Created: 9 Mar 2017, 1:39 p.m.
Comment on phenotypes: Germline and somatic variants also associated with: Denys-Drash syndrome 194080 SMu, AD; Frasier syndrome 136680 SMu, AD; Meacham syndrome 608978; Mesothelioma, somatic 156240; Nephrotic syndrome, type 4 256370 AD; Wilms tumor, type 1 194070 SMu, AD
Created: 9 Mar 2017, 1:39 p.m.
Created: 9 Mar 2017, 1:39 p.m.

Panel version: 0.498

BRIDGE consortium (NIHRBR-RD)

Green List (high evidence)

Mode of inheritance
Unknown

Phenotypes
Acute myeloid leukaemia (AML)

Publications

Variants in this GENE are reported as part of current diagnostic practice

Created: 16 Jan 2017, 3:47 p.m.

Panel version: Imported from "Anaemias and red cell disorders" panel version 0.9

History Filter Activity

11 Mar 2017, Gel status: 1

panel promoted to version 1

Arianna Tucci (Genomics England Curator)

Promoted to V1 on 11 March 2017, after internal review and discussion with the clinical team.

9 Mar 2017, Gel status: 1

Gene classified by Genomics England curator

Sarah Leigh (Genomics England Curator)

This gene has been classified as Red List (Low Evidence).

9 Mar 2017, Gel status: 0

Set Phenotypes

Sarah Leigh (Genomics England Curator)

Phenotypes for WT1 were set to Acute myeloid leukaemia (AML)

9 Mar 2017, Gel status: 0

Set publications

Sarah Leigh (Genomics England Curator)

Publications for WT1 were set to 20368469; 27252512; 8630376

17 Feb 2017, Gel status: 0

Added New Source

Louise Daugherty (Genomics England Curator)

WT1 was added to Cytopaenias and congenital anaemiaspanel. Sources: BRIDGE consortium (NIHRBR-RD)

17 Feb 2017, Gel status: 0

Created

Louise Daugherty (Genomics England Curator)

WT1 was created by LouiseD