Multiple Tumours
Gene: GREM1

GREM1 (gremlin 1, DAN family BMP antagonist)
EnsemblGeneIds (GRCh38): ENSG00000166923
EnsemblGeneIds (GRCh37): ENSG00000166923
OMIM: 603054, Gene2Phenotype
GREM1 is in 8 panels

1 review

Ellen McDonagh (Genomics England Curator)

On the Multiple bowel polyps Version 1.9 gene panel.
Created: 3 May 2017, 12:24 p.m.

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Phenotypes
{Colorectal cancer, increased risk, association with}(Peters (2012) Hum Genet 131,217); Oligosyndactyly of the hands, Cenani-Linz-like (Dimitrov (2010) J Med Genet 47,569); Mixed polyposis syndrome (Jaeger (2012) Nat Genet 44,699); Polyposis Syndrome, Hereditary Mixed, 1; Hereditary Mixed Polyposis Syndrome

Publications

Nat Genet. 2012 May 6 44(6):699-703. doi: 10.1038/ng.2263.

Created: 3 May 2017, 12:24 p.m.

Panel version: 1.80

Details

Mode of Inheritance

MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Sources

Other

Phenotypes

{Colorectal cancer, increased risk, association with}(Peters (2012) Hum Genet 131,217)
Oligosyndactyly of the hands, Cenani-Linz-like (Dimitrov (2010) J Med Genet 47,569)
Mixed polyposis syndrome (Jaeger (2012) Nat Genet 44,699)
Polyposis Syndrome, Hereditary Mixed, 1
Hereditary Mixed Polyposis Syndrome

OMIM

603054

Clinvar variants

Variants in GREM1

Penetrance

Complete

Publications

Nat Genet. 2012 May 6 44(6):699-703. doi: 10.1038/ng.2263.

Panels with this gene

History Filter Activity

3 May 2017, Gel status: 0

Created

Ellen McDonagh (Genomics England Curator)

GREM1 was created by ellenmcdonagh

3 May 2017, Gel status: 0

Added New Source