Viral resistance
Gene: CCL2

CCL2 (C-C motif chemokine ligand 2)
EnsemblGeneIds (GRCh38): ENSG00000108691
EnsemblGeneIds (GRCh37): ENSG00000108691
OMIM: 158105, Gene2Phenotype
CCL2 is in 4 panels

1 review

Ivone Leong (Genomics England Curator)

Comment on list classification: PMID: 14571188 found that three SNPs (-2136T CCL2 promoter region, 767G intron 1 of CCL2 and -1385A of Eotaxin promoter) were nearly always found together on a 31kb haplotype (H7), which contains all three regoins. The frequencies for these three variants and H7 haplotype were significantly increased in uninfected European-Americans who were repeatedly exposed to HIV-1. The study suggests that this region influences HIV susceptibility/resistance.
Created: 5 May 2020, 9:18 a.m. | Last Modified: 5 May 2020, 9:22 a.m.

Panel Version: 0.36

Created: 5 May 2020, 9:18 a.m.
Last Modified: 5 May 2020, 9:22 a.m.
Panel version: 0.36

Details

Sources

Expert Review Red
OMIM

Phenotypes

{HIV-1, resistance to} 609423

OMIM

158105

Clinvar variants

Variants in CCL2

Penetrance

None

Publications

14571188

Panels with this gene

History Filter Activity

5 May 2020, Gel status: 1

Entity classified by Genomics England curator

Ivone Leong (Genomics England Curator)

Gene: ccl2 has been classified as Red List (Low Evidence).

28 Apr 2020, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set publications, Set Phenotypes

Sarah Leigh (Genomics England Curator)

gene: CCL2 was added gene: CCL2 was added to Viral resistance. Sources: OMIM Mode of inheritance for gene: CCL2 was set to Publications for gene: CCL2 were set to 14571188 Phenotypes for gene: CCL2 were set to {HIV-1, resistance to} 609423

Viral resistance Gene: CCL2