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Viral resistance

Gene: TLR3

Green List (high evidence)
TLR3 (toll like receptor 3)
EnsemblGeneIds (GRCh38): ENSG00000164342
EnsemblGeneIds (GRCh37): ENSG00000164342
OMIM: 603029, Gene2Phenotype
TLR3 is in 3 panels

1 review

Ivone Leong (Genomics England Curator)

Comment on list classification: PMID: 22174453 and 23962581 found that rs3775291 (Leu412Phe) confers resistance to HIV-1 infection in Spanish and Estonian HIV-1 exposed seronegative i.v. drug users.

PMID: 20636339 found that activating TLR3 inhibits HIV replication and that TLR3-mediated induction of multiple anti-HIV factors (i.e. type I interferon inducible antiviral factors - APOBEC3G and tetherin) should be beneficial for HIV treatment.

Therefore, there is enough evidence to promote this gene to Green status.
Created: 4 May 2020, 10:43 a.m. | Last Modified: 4 May 2020, 10:43 a.m.
Panel Version: 0.24
Created: 4 May 2020, 10:43 a.m.
Last Modified: 4 May 2020, 10:43 a.m.
Panel version: 0.24

Details

Mode of Inheritance
Unknown
Sources
  • Expert Review Green
  • OMIM
Phenotypes
  • {HIV1 infection, resistance to} 609423
OMIM
603029
Clinvar variants
Variants in TLR3
Penetrance
None
Publications
Panels with this gene

History Filter Activity

4 May 2020, Gel status: 3

Set publications

Ivone Leong (Genomics England Curator)

Publications for gene: TLR3 were set to 20636339

4 May 2020, Gel status: 3

Set mode of inheritance

Ivone Leong (Genomics England Curator)

Mode of inheritance for gene: TLR3 was changed from to Unknown

4 May 2020, Gel status: 3

Entity classified by Genomics England curator

Ivone Leong (Genomics England Curator)

Gene: tlr3 has been classified as Green List (High Evidence).

28 Apr 2020, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set publications, Set Phenotypes

Sarah Leigh (Genomics England Curator)

gene: TLR3 was added gene: TLR3 was added to Viral resistance. Sources: OMIM Mode of inheritance for gene: TLR3 was set to Publications for gene: TLR3 were set to 20636339 Phenotypes for gene: TLR3 were set to {HIV1 infection, resistance to} 609423