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  2. Childhood solid tumours cancer susceptibility
  3. DIS3L2
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Childhood solid tumours cancer susceptibility

Gene: DIS3L2

Green List (high evidence)
DIS3L2 (DIS3 like 3'-5' exoribonuclease 2)
EnsemblGeneIds (GRCh38): ENSG00000144535
EnsemblGeneIds (GRCh37): ENSG00000144535
OMIM: 614184, Gene2Phenotype
DIS3L2 is in 8 panels

1 review

Zornitza Stark (Australian Genomics)

Green List (high evidence)

Increased risk of Wilms tumour.
Created: 1 Aug 2020, 7:44 a.m. | Last Modified: 1 Aug 2020, 7:44 a.m.
Panel Version: 1.6

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Phenotypes
Perlman syndrome, MIM# 267000

Created: 1 Aug 2020, 7:44 a.m.
Last Modified: 1 Aug 2020, 7:44 a.m.
Panel version: 1.6

Details

Mode of Inheritance
BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Green
Phenotypes
  • Perlman syndrome, 267000
OMIM
614184
Clinvar variants
Variants in DIS3L2
Penetrance
None
Panels with this gene

History Filter Activity

10 Aug 2020, Gel status: 3

Entity classified by Genomics England curator

Arina Puzriakova (Genomics England Curator)

Gene: dis3l2 has been classified as Green List (High Evidence).

26 Mar 2019, Gel status: 2

Created, Added New Source, Set mode of inheritance, Set Phenotypes

Ellen McDonagh (Genomics England Curator)

gene: DIS3L2 was added gene: DIS3L2 was added to Childhood solid tumours pertinent cancer susceptibility. Sources: Expert Review Amber Mode of inheritance for gene: DIS3L2 was set to BIALLELIC, autosomal or pseudoautosomal Phenotypes for gene: DIS3L2 were set to Perlman syndrome, 267000