Childhood solid tumours cancer susceptibility

Gene: MSH2

Green List (high evidence)

MSH2 (mutS homolog 2)
EnsemblGeneIds (GRCh38): ENSG00000095002
EnsemblGeneIds (GRCh37): ENSG00000095002
OMIM: 609309, Gene2Phenotype
MSH2 is in 32 panels

2 reviews

Ellen McDonagh (Genomics England Curator)

Comment on mode of inheritance: Feedback from Clare Turnbull: only biallelic variants should be reported back for childhood panel.
20 Jul 2017, 2:58 p.m.
Comment on mode of inheritance: Feedback from Clare Turnbull: only biallelic variants should be reported back for childhood panel.
20 Jul 2017, 2:58 p.m.

Clare Turnbull (Queen Mary University London)

Green List (high evidence)

Tumour suppressor. Report biallelic only.
5 Jul 2017, 11:28 a.m.

Mode of inheritance
BOTH monoallelic and biallelic, autosomal or pseudoautosomal

Phenotypes
Lynch Syndrome; CMMRD

Publications

Details

Mode of Inheritance
BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Green
  • Expert list
Phenotypes
  • Lynch Syndrome
  • CMMRD
OMIM
609309
Clinvar variants
Variants in MSH2
Penetrance
Complete
Publications
Panels with this gene

History Filter Activity

7 Sep 2018, Gel status: 3

Panel promoted to version 1.0

Louise Daugherty (Genomics England Curator)

Clare Turnbull: Tumour suppressor. Report bial

20 Jul 2017, Gel status: 4

Set Mode of Inheritance

Ellen McDonagh (Genomics England Curator)

Mode of inheritance for MSH2 was changed to BIALLELIC, autosomal or pseudoautosomal

20 Jul 2017, Gel status: 4

Set Mode of Inheritance

Ellen McDonagh (Genomics England Curator)

Mode of inheritance for MSH2 was changed to BIALLELIC, autosomal or pseudoautosomal

5 Jul 2017, Gel status: 4

Added New Source

Ellen McDonagh (Genomics England Curator)

MSH2 was added to Childhood solid tumourspanel. Source: Expert Review Green

5 Jul 2017, Gel status: 0

Added New Source

Ellen McDonagh (Genomics England Curator)

MSH2 was added to Childhood solid tumourspanel. Sources: Expert list

5 Jul 2017, Gel status: 0

Created

Ellen McDonagh (Genomics England Curator)

MSH2 was created by ellenmcdonagh