Childhood solid tumours cancer susceptibility
Gene: HRASEnsemblGeneIds (GRCh38): ENSG00000174775
EnsemblGeneIds (GRCh37): ENSG00000174775
OMIM: 190020, Gene2Phenotype
HRAS is in 30 panels
2 reviews
Zornitza Stark (Australian Genomics)
Increased risk of epithelioma, bladder carcinoma, rhabdomyosarcoma, vestibular schwannoma.Created: 1 Aug 2020, 7:59 a.m. | Last Modified: 1 Aug 2020, 7:59 a.m.
Panel Version: 1.6
Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Phenotypes
Costello syndrome, MIM# 218040
Clare Turnbull (Queen Mary University London)
Rasopathy.Created: 5 Jul 2017, 11:28 a.m.
Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Phenotypes
Costello syndrome
Publications
Details
- Mode of Inheritance
- MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
- Sources
-
- Expert Review Green
- Expert list
- Phenotypes
-
- Costello syndrome
- OMIM
- 190020
- Clinvar variants
- Variants in HRAS
- Penetrance
- Complete
- Publications
- Panels with this gene
-
- Adult solid tumours cancer susceptibility
- Monogenic short stature
- Embryonal tumour of possible germline origin
- Primary lymphoedema
- Neurological segmental overgrowth
- Fetal hydrops
- Fetal anomalies
- Hypertrophic cardiomyopathy
- Familial rhabdomyosarcoma
- Sarcoma of possible germline origin
- Congenital myopathy
- Early onset or syndromic epilepsy
- Hereditary neuropathy
- RASopathies
- IUGR and IGF abnormalities
- Pigmentary skin disorders
- Pneumothorax - familial
- Paediatric or syndromic cardiomyopathy
- Childhood solid tumours cancer susceptibility
- Segmental overgrowth disorders - Deep sequencing
- Sarcoma cancer susceptibility
- Cytopenias and congenital anaemias
- Mosaic skin disorders - Deep sequencing
- Intellectual disability
- Arthrogryposis
- Sarcoma susceptibility
- Childhood solid tumours
- Multiple monogenic benign skin tumours
- DDG2P
- Hereditary neuropathy or pain disorder
History Filter Activity
Entity classified by Genomics England curator
Arina Puzriakova (Genomics England Curator)Gene: hras has been classified as Green List (High Evidence).
Added New Source, Set Phenotypes, Status Update
Ellen McDonagh (Genomics England Curator)Source Expert Review Amber was added to HRAS. Added phenotypes Costello syndrome for gene: HRAS Rating Changed from Green List (high evidence) to Amber List (moderate evidence)
Panel promoted to version 1.0
Louise Daugherty (Genomics England Curator)Clare Turnbull: Rasopathy.
Added New Source
Ellen McDonagh (Genomics England Curator)HRAS was added to Childhood solid tumourspanel. Source: Expert Review Green
Added New Source
Ellen McDonagh (Genomics England Curator)HRAS was added to Childhood solid tumourspanel. Sources: Expert list
Created
Ellen McDonagh (Genomics England Curator)HRAS was created by ellenmcdonagh