Childhood solid tumours cancer susceptibilityGene: MAP2K1
Comment on mode of pathogenicity: Loss of function variants should not be reported back in this gene for this panel (confirmed with Clare Turnbull).
30 Jan 2018, 11:38 a.m.
5 Jul 2017, 11:28 a.m.
Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Clare Turnbull: Kinase. Rasopathy.
Mode of pathogenicity for MAP2K1 was changed to Loss-of-function variants (as defined in pop up message) DO NOT cause this phenotype - please provide details in the comments
MAP2K1 was added to Childhood solid tumourspanel. Source: Expert Review Green
MAP2K1 was added to Childhood solid tumourspanel. Sources: Expert list
MAP2K1 was created by ellenmcdonagh