Childhood solid tumours cancer susceptibilityGene: RAD51C
Added 'watchlist' tag after demoting RAD51C from Green to Amber on the basis of a single case report.
31 Jul 2017, 7:41 a.m.
Comment on list classification: Changed rating from Green to Amber based on re-evaluation of supporting evidence. Only 1 reported (biallelic) case supporting the FA phenotype (PMID:20400963). Helen Lindsay (Leeds Genetic Laboratory) also confirmed that there is only 1 reported case in literature and they have not identified any pathogenic mutations in FA patients to date. Agreed with Arianna Tucci and Helen Brittain that RAD51C should therefore be Amber on the basis of this single case report.
31 Jul 2017, 7:40 a.m.
5 Jul 2017, 11:28 a.m.
Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal
Clare Turnbull: Tumour suppressor.
This gene has been classified as Amber List (Moderate Evidence).
RAD51C was added to Childhood solid tumourspanel. Source: Expert Review Green
RAD51C was added to Childhood solid tumourspanel. Sources: Expert list
RAD51C was created by ellenmcdonagh