Childhood solid tumours cancer susceptibility

Gene: RAD51C

Amber List (moderate evidence)

RAD51C (RAD51 paralog C)
EnsemblGeneIds (GRCh38): ENSG00000108384
EnsemblGeneIds (GRCh37): ENSG00000108384
OMIM: 602774, Gene2Phenotype
RAD51C is in 21 panels

2 reviews

Rebecca Foulger (Genomics England curator)

Added 'watchlist' tag after demoting RAD51C from Green to Amber on the basis of a single case report.
31 Jul 2017, 7:41 a.m.
Comment on list classification: Changed rating from Green to Amber based on re-evaluation of supporting evidence. Only 1 reported (biallelic) case supporting the FA phenotype (PMID:20400963). Helen Lindsay (Leeds Genetic Laboratory) also confirmed that there is only 1 reported case in literature and they have not identified any pathogenic mutations in FA patients to date. Agreed with Arianna Tucci and Helen Brittain that RAD51C should therefore be Amber on the basis of this single case report.
31 Jul 2017, 7:40 a.m.

Clare Turnbull (Queen Mary University London)

Green List (high evidence)

Tumour suppressor.
5 Jul 2017, 11:28 a.m.

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Phenotypes
Fanconi Anemia

Publications

History Filter Activity

7 Sep 2018, Gel status: 2

Panel promoted to version 1.0

Louise Daugherty (Genomics England Curator)

Clare Turnbull: Tumour suppressor.

31 Jul 2017, Gel status: 2

Gene classified by Genomics England curator

Rebecca Foulger (Genomics England curator)

This gene has been classified as Amber List (Moderate Evidence).

5 Jul 2017, Gel status: 4

Added New Source

Ellen McDonagh (Genomics England Curator)

RAD51C was added to Childhood solid tumourspanel. Source: Expert Review Green

5 Jul 2017, Gel status: 0

Added New Source

Ellen McDonagh (Genomics England Curator)

RAD51C was added to Childhood solid tumourspanel. Sources: Expert list

5 Jul 2017, Gel status: 0

Created

Ellen McDonagh (Genomics England Curator)

RAD51C was created by ellenmcdonagh