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  3. CCDC151
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Fetal anomalies

Gene: CCDC151

Green List (high evidence)
CCDC151 (coiled-coil domain containing 151)
EnsemblGeneIds (GRCh38): ENSG00000198003
EnsemblGeneIds (GRCh37): ENSG00000198003
OMIM: 615956, Gene2Phenotype
CCDC151 is in 6 panels

4 reviews

Catherine Snow (Genomics England)

Added new-gene-name tag, new approved HGNC gene symbol for CCDC151 is ODAD3
Created: 24 Feb 2021, 5:08 p.m. | Last Modified: 24 Feb 2021, 5:08 p.m.
Panel Version: 1.628
Created: 24 Feb 2021, 5:08 p.m.
Last Modified: 24 Feb 2021, 5:08 p.m.
Panel version: 1.628

Arina Puzriakova (Genomics England Curator)

The rating of this gene has been updated following NHS Genomic Medicine Service approval.
Created: 3 Mar 2022, 11:19 a.m. | Last Modified: 3 Mar 2022, 11:19 a.m.
Panel Version: 1.836
Comment on list classification: Following curation and clinical review at GOSH it has been agreed that the associated phenotype is fetally-relevant. Therefore this gene should be promoted to Green at the next GMS panel update (added 'for-review' tag)
Created: 1 Feb 2021, 11:21 a.m. | Last Modified: 1 Feb 2021, 11:21 a.m.
Panel Version: 1.331
Created: 1 Feb 2021, 11:21 a.m.
Last Modified: 1 Feb 2021, 11:21 a.m.
Panel version: 1.836

Rhiannon Mellis (Great Ormond Street Hospital)

Green List (high evidence)

This gene and phenotype were reviewed during meetings at Great Ormond Street hospital in October 2020. This gene has a Green evidence rating on at least one other related PanelApp panel. Clinical review and curation was performed by Lyn Chitty, Rhiannon Mellis, and Richard Scott. Outcome of review: Confirmed that phenotype is fetally-relevant: add to the Fetal anomalies panel as a Green gene.

Green on related panel(s): Laterality disorders and isomerism; Primary ciliary disorders
Created: 29 Jan 2021, 12:16 p.m. | Last Modified: 29 Jan 2021, 12:16 p.m.
Panel Version: 1.229

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Phenotypes
Ciliary dyskinesia, primary, 30, 616037

Created: 29 Jan 2021, 12:16 p.m.
Last Modified: 29 Jan 2021, 12:16 p.m.
Panel version: 1.229

Rebecca Foulger (Genomics England curator)

I don't know

DDG2P rating in original PAGE list: Probable for PRIMARY CILLARY DYSKINEASIA
Created: 11 Dec 2018, 9:04 a.m.
Created: 11 Dec 2018, 9:04 a.m.

Panel version: 0.9

Details

Mode of Inheritance
BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Green
  • PAGE DD-Gene2Phenotype
Phenotypes
  • Ciliary dyskinesia, primary, 30, OMIM:616037
  • Primary ciliary dyskinesia 30, MONDO:0014465
Tags
new-gene-name
OMIM
615956
Clinvar variants
Variants in CCDC151
Penetrance
None
Panels with this gene

History Filter Activity

3 Mar 2022, Gel status: 3

Removed Tag

Arina Puzriakova (Genomics England Curator)

Tag for-review was removed from gene: CCDC151.

3 Mar 2022, Gel status: 3

Added New Source, Status Update

Arina Puzriakova (Genomics England Curator)

Source Expert Review Green was added to CCDC151. Rating Changed from Amber List (moderate evidence) to Green List (high evidence)

24 Feb 2021, Gel status: 2

Added Tag

Catherine Snow (Genomics England)

Tag new-gene-name tag was added to gene: CCDC151.

1 Feb 2021, Gel status: 2

Set Phenotypes

Arina Puzriakova (Genomics England Curator)

Phenotypes for gene: CCDC151 were changed from PRIMARY CILLARY DYSKINEASIA to Ciliary dyskinesia, primary, 30, OMIM:616037; Primary ciliary dyskinesia 30, MONDO:0014465

1 Feb 2021, Gel status: 2

Entity classified by Genomics England curator

Arina Puzriakova (Genomics England Curator)

Gene: ccdc151 has been classified as Amber List (Moderate Evidence).

1 Feb 2021, Gel status: 2

Added Tag

Arina Puzriakova (Genomics England Curator)

Tag for-review tag was added to gene: CCDC151.

8 Nov 2018, Gel status: 2

Created, Added New Source, Set mode of inheritance, Set Phenotypes

Rebecca Foulger (Genomics England curator)

gene: CCDC151 was added gene: CCDC151 was added to Fetal anomalies. Sources: PAGE DD-Gene2Phenotype,Expert Review Amber Mode of inheritance for gene: CCDC151 was set to BIALLELIC, autosomal or pseudoautosomal Phenotypes for gene: CCDC151 were set to PRIMARY CILLARY DYSKINEASIA