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Fetal anomalies

Gene: WNT3

Amber List (moderate evidence)

WNT3 (Wnt family member 3)
EnsemblGeneIds (GRCh38): ENSG00000108379
EnsemblGeneIds (GRCh37): ENSG00000108379
OMIM: 165330, Gene2Phenotype
WNT3 is in 9 panels

1 review

Rebecca Foulger (Genomics England curator)

I don't know

Comment when marking as ready: Marked WNT3 as ready following clinical review, and review of evidence. April 29th 2019.
Created: 29 Apr 2019, 2:56 p.m.
This gene and phenotype were reviewed during meetings at Great Ormond Street hospital in March and April 2019. Clinical review and curation was performed by Lyn Chitty, Anna de Burca, Rhiannon Mellis, Richard Scott, Ellen McDonagh and Rebecca Foulger. Outcome of review: Phenotype is fetally-relevant but limited evidence: include on the Fetal anomalies panel as an Amber gene. Additional notes from clinical review: Currently insufficient evidence for fetally-relevant Tetra-Amelia syndrome.
Created: 29 Apr 2019, 2:52 p.m.
Despite a disease confidence rating of 'confirmed' in DDG2P, there is limited evidence for the association of WNT3 with Tetra-Amelia syndrome: 2 fetuses from 1 consanguineous Turkish family were reported in PMID:14872406 (2004). PMID:16283889 and PMID:18837045 ruled out WNT3 as a cause for tetra-amelia in their cases.
Created: 4 Apr 2019, 2:10 p.m.
DDG2P rating in original PAGE list: Confirmed for TETRA-AMELIA SYNDROME
Created: 11 Dec 2018, 9:05 a.m.

Details

Mode of Inheritance
BIALLELIC, autosomal or pseudoautosomal
Sources
Phenotypes
  • TETRA-AMELIA SYNDROME
OMIM
165330
Clinvar variants
Variants in WNT3
Penetrance
None
Publications
Panels with this gene

History Filter Activity

29 Apr 2019, Gel status: 2

Entity classified by Genomics England curator

Rebecca Foulger (Genomics England curator)

Gene: wnt3 has been classified as Amber List (Moderate Evidence).

29 Apr 2019, Gel status: 2

Added New Source, Status Update

Rebecca Foulger (Genomics England curator)

Source Expert Review Amber was added to WNT3. Rating Changed from Green List (high evidence) to Amber List (moderate evidence)

4 Apr 2019, Gel status: 4

Set publications

Rebecca Foulger (Genomics England curator)

Publications for gene: WNT3 were set to 14872406

4 Apr 2019, Gel status: 4

Set publications

Rebecca Foulger (Genomics England curator)

Publications for gene: WNT3 were set to

8 Nov 2018, Gel status: 4

Created, Added New Source, Set mode of inheritance, Set Phenotypes

Rebecca Foulger (Genomics England curator)

gene: WNT3 was added gene: WNT3 was added to Fetal anomalies. Sources: Expert Review Green,PAGE DD-Gene2Phenotype Mode of inheritance for gene: WNT3 was set to BIALLELIC, autosomal or pseudoautosomal Phenotypes for gene: WNT3 were set to TETRA-AMELIA SYNDROME