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  3. GAS8
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Fetal anomalies

Gene: GAS8

Red List (low evidence)
GAS8 (growth arrest specific 8)
EnsemblGeneIds (GRCh38): ENSG00000141013
EnsemblGeneIds (GRCh37): ENSG00000141013
OMIM: 605178, Gene2Phenotype
GAS8 is in 7 panels

2 reviews

Achchuthan Shanmugasundram (Genomics England Curator)

The 'new-gene-name' tag has been added as the official HGNC gene symbol for GAS8 is DRC4.
Created: 28 Apr 2025, 11:23 a.m. | Last Modified: 28 Apr 2025, 11:23 a.m.
Panel Version: 5.98
Created: 28 Apr 2025, 11:23 a.m.
Last Modified: 28 Apr 2025, 11:23 a.m.
Panel version: 5.98

Rebecca Foulger (Genomics England curator)

Red List (low evidence)

This gene and phenotype were discussed during review of borderline cases in April 2019. Clinical review and curation was performed by Lyn Chitty, Anna de Burca, Rhiannon Mellis, Richard Scott, Ellen McDonagh and Rebecca Foulger. Outcome of review: Phenotype is not fetally-relevant. Additional notes from clinical review: Primary Ciliary Dyskinesia (PCD) but highly unlikely to cause situs defects. According to PMID:30166424 (Best et al., 2019), GAS8 has not previously been associated with Situs defects in the literature. Plus email correspondance from Hannah Mitchison (UCL) that mutations in GAS8 are not associated with laterality defects, including in mice. Action taken: Demoted gene rating from Green to Red.
Created: 18 Apr 2019, 11:28 a.m.
DDG2P rating in original PAGE list: Confirmed for PRIMARY CILIARY DYSKINESIA
Created: 11 Dec 2018, 9:05 a.m.

Publications

Created: 11 Dec 2018, 9:05 a.m.

Panel version: 0.166

Details

Mode of Inheritance
BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Red
  • PAGE DD-Gene2Phenotype
Phenotypes
  • PRIMARY CILIARY DYSKINESIA
Tags
new-gene-name
OMIM
605178
Clinvar variants
Variants in GAS8
Penetrance
None
Publications
Panels with this gene

History Filter Activity

28 Apr 2025, Gel status: 1

Added Tag

Achchuthan Shanmugasundram (Genomics England Curator)

Tag new-gene-name tag was added to gene: GAS8.

18 Apr 2019, Gel status: 1

Added New Source, Set publications, Status Update

Rebecca Foulger (Genomics England curator)

Source Expert Review Red was added to GAS8. Publications for gene GAS8 were changed from to 30166424 Rating Changed from Green List (high evidence) to Red List (low evidence)

8 Nov 2018, Gel status: 4

Created, Added New Source, Set mode of inheritance, Set Phenotypes

Rebecca Foulger (Genomics England curator)

gene: GAS8 was added gene: GAS8 was added to Fetal anomalies. Sources: Expert Review Green,PAGE DD-Gene2Phenotype Mode of inheritance for gene: GAS8 was set to BIALLELIC, autosomal or pseudoautosomal Phenotypes for gene: GAS8 were set to PRIMARY CILIARY DYSKINESIA