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  3. WNT11
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Fetal anomalies

Gene: WNT11

Amber List (moderate evidence)
WNT11 (Wnt family member 11)
EnsemblGeneIds (GRCh38): ENSG00000085741
EnsemblGeneIds (GRCh37): ENSG00000085741
OMIM: 603699, Gene2Phenotype
WNT11 is in 2 panels

2 reviews

Ida Ertmanska (Genomics England Curator)

This gene and phenotype were reviewed during meetings in July and August 2026. The meetings included representatives of the North Thames and Central and South R21 testing GLHs and from the R21 Clinical Oversight Group. Clinical review and curation was performed by Natalie Chandler & Louise Carr (North Thames GLH), Sarah Graham & Elizabeth Young (Central & South GLH), and Alice Gardham, Esther Kinning, Vicki Harrison, Anna DeBurca, Natalie Canham, Sunayna Best, Soo-Mi Park & Tessa Homfray (R21 Clinical Oversight Group).
Created: 29 Oct 2026, 4:13 p.m. | Last Modified: 29 Oct 2026, 4:13 p.m.
Panel Version: 8.26
Created: 29 Oct 2026, 4:13 p.m.
Last Modified: 29 Oct 2026, 4:13 p.m.
Panel version: 8.26

Natalie Chandler (North Thames GLH)

I don't know

Green in OI panel UK panelapp, same in Aus. PMID: 348750643 cases and functional data. Osteopetrosis - earliest fracture 4 yo. PMID: 38275609 WNT11 missese segregating in 4 members of family with split hand / foot some severe with tibial aplasia with femur bifurcation, ipsilateral bifurcation of the thigh bone. Noted in gnomAD as well. 40200693 biallelic hom LOF variant baby with situs inversus totalis, complex heart defects and renal hypodysplasia. Amber
Created: 29 Oct 2026, 3:51 p.m. | Last Modified: 29 Oct 2026, 3:51 p.m.
Panel Version: 8.25

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Phenotypes
osteopetrosis, MONDO:0017198

Publications

Created: 29 Oct 2026, 3:51 p.m.
Last Modified: 29 Oct 2026, 3:51 p.m.
Panel version: 8.25

Details

Mode of Inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Sources
  • NHS GMS
  • Expert Review Amber
Phenotypes
  • osteopetrosis, MONDO:0017198
OMIM
603699
Clinvar variants
Variants in WNT11
Penetrance
None
Publications
Panels with this gene

History Filter Activity

29 Oct 2026, Gel status: 2

Created, Added New Source, Set mode of inheritance, Set publications, Set Phenotypes

Ida Ertmanska (Genomics England Curator)

gene: WNT11 was added gene: WNT11 was added to Fetal anomalies. Sources: Expert Review Amber,NHS GMS Mode of inheritance for gene: WNT11 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted Publications for gene: WNT11 were set to 34875064; 38275609; 40200693 Phenotypes for gene: WNT11 were set to osteopetrosis, MONDO:0017198