1. Panels
  2. Fetal anomalies
  3. MGRN1
Genes in panel
Prev Next

Fetal anomalies

Gene: MGRN1

Amber List (moderate evidence)
MGRN1 (mahogunin ring finger 1)
EnsemblGeneIds (GRCh38): ENSG00000102858
EnsemblGeneIds (GRCh37): ENSG00000102858
OMIM: 607559, Gene2Phenotype
MGRN1 is in 1 panel

2 reviews

Ida Ertmanska (Genomics England Curator)

This gene and phenotype were reviewed during meetings in July and August 2026. The meetings included representatives of the North Thames and Central and South R21 testing GLHs and from the R21 Clinical Oversight Group. Clinical review and curation was performed by Natalie Chandler & Louise Carr (North Thames GLH), Sarah Graham & Elizabeth Young (Central & South GLH), and Alice Gardham, Esther Kinning, Vicki Harrison, Anna DeBurca, Natalie Canham, Sunayna Best, Soo-Mi Park & Tessa Homfray (R21 Clinical Oversight Group).
Created: 29 Oct 2026, 4:13 p.m. | Last Modified: 29 Oct 2026, 4:13 p.m.
Panel Version: 8.26
Created: 29 Oct 2026, 4:13 p.m.
Last Modified: 29 Oct 2026, 4:13 p.m.
Panel version: 8.26

Natalie Chandler (North Thames GLH)

I don't know

Not reviewed on any panels or on OMIM. PMID 41781207 non-consanguneous Estonian family 6 pregnancies two TOP 12-13 weeks complex CHDs & laterality abnomralities. 1 early misacariiage, 3 healthy children. Hom missense variant in both TOP fetuses. Mouse model recessive variant abnormal early embryonic patterning, left-right axis defects and prenatal lethality due to complex congenital heart malformations with variable penetrance. SIngle case and mice - likley lethal. Amber.
Created: 29 Oct 2026, 3:51 p.m. | Last Modified: 29 Oct 2026, 3:51 p.m.
Panel Version: 8.25

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Phenotypes
visceral heterotaxy, MONDO:0018677

Publications

Created: 29 Oct 2026, 3:51 p.m.
Last Modified: 29 Oct 2026, 3:51 p.m.
Panel version: 8.25

Details

Mode of Inheritance
BIALLELIC, autosomal or pseudoautosomal
Sources
  • NHS GMS
  • Expert Review Amber
Phenotypes
  • visceral heterotaxy, MONDO:0018677
OMIM
607559
Clinvar variants
Variants in MGRN1
Penetrance
None
Publications
Panels with this gene

History Filter Activity

29 Oct 2026, Gel status: 2

Created, Added New Source, Set mode of inheritance, Set publications, Set Phenotypes

Ida Ertmanska (Genomics England Curator)

gene: MGRN1 was added gene: MGRN1 was added to Fetal anomalies. Sources: Expert Review Amber,NHS GMS Mode of inheritance for gene: MGRN1 was set to BIALLELIC, autosomal or pseudoautosomal Publications for gene: MGRN1 were set to 41781207 Phenotypes for gene: MGRN1 were set to visceral heterotaxy, MONDO:0018677