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  3. ZFPM1
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Fetal anomalies

Gene: ZFPM1

Red List (low evidence)
ZFPM1 (zinc finger protein, FOG family member 1)
EnsemblGeneIds (GRCh38): ENSG00000179588
EnsemblGeneIds (GRCh37): ENSG00000179588
OMIM: 601950, Gene2Phenotype
ZFPM1 is in 1 panel

2 reviews

Ida Ertmanska (Genomics England Curator)

This gene and phenotype were reviewed during meetings in July and August 2026. The meetings included representatives of the North Thames and Central and South R21 testing GLHs and from the R21 Clinical Oversight Group. Clinical review and curation was performed by Natalie Chandler & Louise Carr (North Thames GLH), Sarah Graham & Elizabeth Young (Central & South GLH), and Alice Gardham, Esther Kinning, Vicki Harrison, Anna DeBurca, Natalie Canham, Sunayna Best, Soo-Mi Park & Tessa Homfray (R21 Clinical Oversight Group).
Created: 29 Oct 2026, 4:13 p.m. | Last Modified: 29 Oct 2026, 4:13 p.m.
Panel Version: 8.26
Created: 29 Oct 2026, 4:13 p.m.
Last Modified: 29 Oct 2026, 4:13 p.m.
Panel version: 8.26

Esther Kinning (NHS Greater Glasgow and Clyde)

Red List (low evidence)

not on any other panels yet, one report of a deletion including this gene but many others in a fetus with AVSD and dysmorphism
Created: 29 Oct 2026, 3:51 p.m. | Last Modified: 29 Oct 2026, 3:51 p.m.
Panel Version: 8.25

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Phenotypes
congenital heart disease, MONDO:0005453

Publications

Created: 29 Oct 2026, 3:51 p.m.
Last Modified: 29 Oct 2026, 3:51 p.m.
Panel version: 8.25

Details

Mode of Inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Sources
  • Expert Review Red
  • NHS GMS
Phenotypes
  • congenital heart disease, MONDO:0005453
OMIM
601950
Clinvar variants
Variants in ZFPM1
Penetrance
None
Publications
Panels with this gene

History Filter Activity

29 Oct 2026, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set publications, Set Phenotypes

Ida Ertmanska (Genomics England Curator)

gene: ZFPM1 was added gene: ZFPM1 was added to Fetal anomalies. Sources: NHS GMS,Expert Review Red Mode of inheritance for gene: ZFPM1 was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted Publications for gene: ZFPM1 were set to 41813389 Phenotypes for gene: ZFPM1 were set to congenital heart disease, MONDO:0005453