Fetal anomalies
Gene: TGIF1

TGIF1 (TGFB induced factor homeobox 1)
EnsemblGeneIds (GRCh38): ENSG00000177426
EnsemblGeneIds (GRCh37): ENSG00000177426
OMIM: 602630, Gene2Phenotype
TGIF1 is in 7 panels

1 review

Rebecca Foulger (Genomics England curator)

Green List (high evidence)

This gene and phenotype were reviewed during meetings at Great Ormond Street hospital in March 2019. Clinical review and curation was performed by Lyn Chitty, Anna de Burca, Rhiannon Mellis, Richard Scott, Ellen McDonagh and Rebecca Foulger. Outcome of review: Confirmed that phenotype is fetally-relevant: keep on the Fetal anomalies panel as a Green gene.
Created: 24 Mar 2019, 4:30 p.m.

DDG2P rating in original PAGE list: Confirmed for HOLOPROSENCEPHALY, and Confirmed for Holoprosencephaly 4 142946 from Additional Genes List.
Created: 11 Dec 2018, 9:05 a.m.

Created: 11 Dec 2018, 9:05 a.m.

Panel version: 0.134

Details

Mode of Inheritance

MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Sources

PAGE Additional Gene List
PAGE DD-Gene2Phenotype
Expert Review Green

Phenotypes

Holoprosencephaly 4 142946
HOLOPROSENCEPHALY

OMIM

602630

Clinvar variants

Variants in TGIF1

Penetrance

None

Panels with this gene

History Filter Activity

8 Nov 2018, Gel status: 4

Added New Source, Set Phenotypes

Rebecca Foulger (Genomics England curator)

Source PAGE Additional Gene List was added to TGIF1. Added phenotypes Holoprosencephaly 4 142946 for gene: TGIF1

8 Nov 2018, Gel status: 4

Created, Added New Source, Set mode of inheritance, Set Phenotypes

Rebecca Foulger (Genomics England curator)

gene: TGIF1 was added gene: TGIF1 was added to Fetal anomalies. Sources: Expert Review Green,PAGE DD-Gene2Phenotype Mode of inheritance for gene: TGIF1 was set to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown Phenotypes for gene: TGIF1 were set to HOLOPROSENCEPHALY

Fetal anomalies Gene: TGIF1