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  3. TTC26
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Fetal anomalies

Gene: TTC26

Green List (high evidence)
TTC26 (tetratricopeptide repeat domain 26)
EnsemblGeneIds (GRCh38): ENSG00000105948
EnsemblGeneIds (GRCh37): ENSG00000105948
OMIM: 617453, Gene2Phenotype
TTC26 is in 2 panels

3 reviews

Ida Ertmanska (Genomics England Curator)

Added new-gene-name tag, new approved HGNC gene symbol for TTC26 is IFT56.
Created: 19 Mar 2026, 3:44 p.m. | Last Modified: 19 Mar 2026, 3:44 p.m.
Panel Version: 6.165
Created: 19 Mar 2026, 3:44 p.m.
Last Modified: 19 Mar 2026, 3:44 p.m.
Panel version: 6.165

Arina Puzriakova (Genomics England Curator)

Green List (high evidence)

The rating of this gene has been updated to Green and the mode of inheritance set to BIALLELIC, autosomal or pseudoautosomal following NHS Genomic Medicine Service approval.
Created: 10 Mar 2026, 12:27 p.m. | Last Modified: 10 Mar 2026, 12:27 p.m.
Panel Version: 6.149
This gene and phenotype were reviewed during meetings between November 2025 & January 2026. The meetings included representatives of the Central & South and North Thames R21 testing GLHs and from the R21 Clinical Oversight Group. Clinical review and curation was performed by Stephanie Allen, Elizabeth Young and Sarah Graham (Central & South GLH), Natalie Chandler and Elizabeth Scotchman (North Thames GLH), and Tazeen Ashraf, Anna De Burca, Natalie Canham, Samantha Doyle, Alice Gardham, Victoria Harrison, Tessa Homfray, Esther Kinning, and Soo-Mi Park (R21 Clinical Oversight Group).
Created: 10 Mar 2026, 11:35 a.m. | Last Modified: 10 Mar 2026, 11:35 a.m.
Panel Version: 6.148
Created: 10 Mar 2026, 11:35 a.m.
Last Modified: 10 Mar 2026, 11:35 a.m.
Panel version: 6.150

Natalie Chandler (North Thames GLH)

Green List (high evidence)

Not reviewed in panel app uk or clingen, green in Aus panel app. Aus claim 9 families and zebrafish with ciliopathy. PMID 3417742 Hom splice variaant polyhydramnios and atrioventricular septal defect prenatally dysmorphic features in the form of deep-set eyes, low-set ears, frontal bossing, hypermobile and extensible joints, polydactyly in the upper limbs, and syndactyly in the lower limbs at birth. PMID ;32617964 hom misssense in 4 probands 2 diff families, same varaint Israel. Brain MRI 3/4 Ectopic/absent neurohypophysis with absent stalk, 2 cardiac, 3/4 polydactyly. 31595528 abstract only 7 individuals 7 families 3 diff hom varaints. No detailed phenotye in abstract (edge issues). PMID 24596149;22718903 Zebrafish -short cilia and motility defect. Suggest green - some prenatal feeatures and enough cases. Other ciliopathy genes on panel
Created: 10 Mar 2026, 11:27 a.m. | Last Modified: 10 Mar 2026, 11:27 a.m.
Panel Version: 6.147

Mode of inheritance
BIALLELIC, autosomal or pseudoautosomal

Phenotypes
Biliary, renal, neurologic, and skeletal syndrome, OMIM:619534

Publications

Created: 10 Mar 2026, 11:27 a.m.
Last Modified: 10 Mar 2026, 11:27 a.m.
Panel version: 6.147

Details

Mode of Inheritance
BIALLELIC, autosomal or pseudoautosomal
Sources
  • Expert Review Green
Phenotypes
  • Biliary, renal, neurologic, and skeletal syndrome, OMIM:619534
Tags
new-gene-name
OMIM
617453
Clinvar variants
Variants in TTC26
Penetrance
None
Panels with this gene

History Filter Activity

19 Mar 2026, Gel status: 3

Added Tag

Ida Ertmanska (Genomics England Curator)

Tag new-gene-name tag was added to gene: TTC26.

10 Mar 2026, Gel status: 3

Set Phenotypes

Arina Puzriakova (Genomics England Curator)

Added phenotypes Biliary, renal, neurologic, and skeletal syndrome, OMIM:619534 for gene: TTC26

9 Mar 2026, Gel status: 3

Created, Added New Source, Set mode of inheritance

Arina Puzriakova (Genomics England Curator)

gene: TTC26 was added gene: TTC26 was added to Fetal anomalies. Sources: Expert Review Green Mode of inheritance for gene: TTC26 was set to BIALLELIC, autosomal or pseudoautosomal