Inherited renal cancer

Gene: CDKN2B

Amber List (moderate evidence)

CDKN2B (cyclin dependent kinase inhibitor 2B)
EnsemblGeneIds (GRCh38): ENSG00000147883
EnsemblGeneIds (GRCh37): ENSG00000147883
OMIM: 600431, Gene2Phenotype
CDKN2B is in 2 panels

2 reviews

Ivone Leong (Genomics England Curator)

As discussed in the GMS Inherited Cancer Specialist Test Group webex call 31st Jan 2019: The Specialist Test Group agreed that this gene should be rated amber.
Created: 1 Feb 2019, 9:46 a.m. | Last Modified: 31 Jul 2019, 12:56 p.m.
Panel Version: 0.38

Rachel Robinson (Leeds Genetics Laboratory)

Green List (high evidence)

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Details

Mode of Inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Sources
  • Expert Review Amber
OMIM
600431
Clinvar variants
Variants in CDKN2B
Penetrance
None
Publications
Panels with this gene

History Filter Activity

1 Feb 2019, Gel status: 2

Entity classified by Genomics England curator

Ivone Leong (Genomics England Curator)

Gene: cdkn2b has been classified as Amber List (Moderate Evidence).

31 Jan 2019, Gel status: 2

Entity classified by Genomics England curator

Ivone Leong (Genomics England Curator)

Gene: cdkn2b has been classified as Amber List (Moderate Evidence).

30 Jan 2019, Gel status: 3

Set publications

Ivone Leong (Genomics England Curator)

Publications for gene: CDKN2B were set to PMID:25873077

30 Jan 2019, Gel status: 3

Entity classified by Genomics England curator

Ivone Leong (Genomics England Curator)

Gene: cdkn2b has been classified as Green List (High Evidence).

28 Dec 2018, Gel status: 0

Created, Added New Source, Set mode of inheritance, Set publications

Rachel Robinson (Leeds Genetics Laboratory)

gene: CDKN2B was added gene: CDKN2B was added to Inherited renal cancer. Sources: UKGTN Mode of inheritance for gene: CDKN2B was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted Publications for gene: CDKN2B were set to PMID:25873077 gene: CDKN2B was marked as current diagnostic