Inherited renal cancer

Gene: PMS2

No list

PMS2 (PMS1 homolog 2, mismatch repair system component)
EnsemblGeneIds (GRCh38): ENSG00000122512
EnsemblGeneIds (GRCh37): ENSG00000122512
OMIM: 600259, Gene2Phenotype
PMS2 is in 34 panels

3 reviews

Ivone Leong (Genomics England Curator)

Comment on list classification: As discussed in the GMS Inherited Cancer Specialist Test Group webex call 31st Jan 2019: The Specialist Test Group agreed that this gene should be removed from the panel as it is associated with TCC and not RCC. Therefore, this gene has been made grey.
Created: 1 Feb 2019, 10:05 a.m.

Lara Hawkes (Genomics England)

I don't know

Ellen McDonagh (Genomics England Curator)

This gene was added after request from Clare Turnbull (Cancer Clinical Team, Genomics England), and confirmed by Lara Hawkes (Cancer Clinical Team, Genomics England) that this addition is correct.
Created: 20 Aug 2018, 1:28 p.m.

History Filter Activity

1 Feb 2019, Gel status: 0

Entity classified by Genomics England curator

Ivone Leong (Genomics England Curator)

Gene: pms2 has been removed from the panel.

30 Jan 2019, Gel status: 2

Set mode of inheritance

Ivone Leong (Genomics England Curator)

Mode of inheritance for gene: PMS2 was changed from to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

30 Jan 2019, Gel status: 2

Entity classified by Genomics England curator

Ivone Leong (Genomics England Curator)

Gene: pms2 has been classified as Amber List (Moderate Evidence).

30 Jan 2019, Gel status: 1

Created, Added New Source, Set mode of inheritance

Ivone Leong (Genomics England Curator)

gene: PMS2 was added gene: PMS2 was added to Inherited renal cancer. Sources: Expert List Mode of inheritance for gene: PMS2 was set to