Inherited renal cancer

Gene: MLH1

No list

MLH1 (mutL homolog 1)
EnsemblGeneIds (GRCh38): ENSG00000076242
EnsemblGeneIds (GRCh37): ENSG00000076242
OMIM: 120436, Gene2Phenotype
MLH1 is in 35 panels

3 reviews

Ivone Leong (Genomics England Curator)

Comment on list classification: As discussed in the GMS Inherited Cancer Specialist Test Group webex call 31st Jan 2019: The Specialist Test Group agreed that this gene should be removed from the panel as it is associated with TCC and not RCC. Therefore, this gene has been made grey.
Created: 1 Feb 2019, 10:04 a.m.

Lara Hawkes (Genomics England)

I don't know

Ellen McDonagh (Genomics England Curator)

This gene was added after request from Clare Turnbull (Cancer Clinical Team, Genomics England), and confirmed by Lara Hawkes (Cancer Clinical Team, Genomics England) that this addition is correct.
Created: 20 Aug 2018, 1:27 p.m.

Details

Mode of Inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Sources
  • Expert Review Removed
  • Expert List
  • Expert list
Tags
curated_removed
OMIM
120436
Clinvar variants
Variants in MLH1
Penetrance
None
Panels with this gene

History Filter Activity

26 Feb 2021, Gel status: 0

Added Tag

Arina Puzriakova (Genomics England Curator)

Tag curated_removed tag was added to gene: MLH1.

1 Feb 2019, Gel status: 0

Entity classified by Genomics England curator

Ivone Leong (Genomics England Curator)

Gene: mlh1 has been removed from the panel.

30 Jan 2019, Gel status: 2

Set mode of inheritance

Ivone Leong (Genomics England Curator)

Mode of inheritance for gene: MLH1 was changed from to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

30 Jan 2019, Gel status: 2

Entity classified by Genomics England curator

Ivone Leong (Genomics England Curator)

Gene: mlh1 has been classified as Amber List (Moderate Evidence).

30 Jan 2019, Gel status: 1

Created, Added New Source, Set mode of inheritance

Ivone Leong (Genomics England Curator)

gene: MLH1 was added gene: MLH1 was added to Inherited renal cancer. Sources: Expert List Mode of inheritance for gene: MLH1 was set to