Inherited renal cancer

Gene: SDHD

Amber List (moderate evidence)

SDHD (succinate dehydrogenase complex subunit D)
EnsemblGeneIds (GRCh38): ENSG00000204370
EnsemblGeneIds (GRCh37): ENSG00000204370
OMIM: 602690, Gene2Phenotype
SDHD is in 24 panels

2 reviews

Ivone Leong (Genomics England Curator)

As discussed in the GMS Inherited Cancer Specialist Test Group webex call 31st Jan 2019: The Specialist Test Group agreed that this gene should be rated amber.
Created: 1 Feb 2019, 9:46 a.m. | Last Modified: 31 Jul 2019, 12:57 p.m.
Panel Version: 0.38

Rachel Robinson (Leeds Genetics Laboratory)

Green List (high evidence)

SDHD linked pedigrees exhibit a clear parent-of-origin effect: inheritance of paraganglioma commonly occurs in an autosomal dominant way only when paternally transmitted. There are a few reports of SDHD-related disease with maternal transmission. The SDHD gene is not imprinted, SDHD-linked tumours arise upon paternal transmission of the mutation on selective loss of the entire maternal chromosome 11 (PMID: 15064708).
Sources: UKGTN
Created: 28 Dec 2018, 10:53 a.m.

Mode of inheritance
Other

Publications

Variants in this GENE are reported as part of current diagnostic practice

History Filter Activity

15 Oct 2019, Gel status: 2

Set publications

Rebecca Foulger (Genomics England curator)

Publications for gene: SDHD were set to PMID: 27899189

1 Feb 2019, Gel status: 2

Entity classified by Genomics England curator

Ivone Leong (Genomics England Curator)

Gene: sdhd has been classified as Amber List (Moderate Evidence).

31 Jan 2019, Gel status: 2

Entity classified by Genomics England curator

Ivone Leong (Genomics England Curator)

Gene: sdhd has been classified as Amber List (Moderate Evidence).

30 Jan 2019, Gel status: 3

Entity classified by Genomics England curator

Ivone Leong (Genomics England Curator)

Gene: sdhd has been classified as Green List (High Evidence).

28 Dec 2018, Gel status: 0

Created, Added New Source, Set mode of inheritance, Set publications, Set penetrance

Rachel Robinson (Leeds Genetics Laboratory)

gene: SDHD was added gene: SDHD was added to Inherited renal cancer. Sources: UKGTN Mode of inheritance for gene: SDHD was set to Other Publications for gene: SDHD were set to PMID: 27899189 Penetrance for gene: SDHD were set to Complete Review for gene: SDHD was set to GREEN gene: SDHD was marked as current diagnostic