Inherited renal cancer
Gene: FLCNComment on phenotypes: This gene is also associated with Colorectal cancer, somatic (MIM# 114500); Pneumothorax, primary spontaneous (MIM# 173600); Renal carcinoma, chromophobe, somatic (MIM# 144700)Created: 8 Mar 2021, 1:06 p.m. | Last Modified: 8 Mar 2021, 1:06 p.m.
Panel Version: 1.8
As discussed in the GMS Inherited Cancer Specialist Test Group webex call 31st Jan 2019: The Specialist Test Group agreed that there is enough evidence to rate this gene green.Created: 31 Jul 2019, 12:50 p.m. | Last Modified: 31 Jul 2019, 12:50 p.m.
Panel Version: 0.38
Sources: UKGTNCreated: 28 Dec 2018, 9:27 a.m.
Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Phenotypes
Renal carcinoma; Parotid oncocytomas; Neural tissue tumors; Lipomas; Angiolipomas
Publications
Variants in this GENE are reported as part of current diagnostic practice
Comment on list classification: Details checked against the Gene List for Reporting Germline Findings in Cancer Patients Version 1.5 document, for renal tumour type.Created: 26 Jul 2017, 12:14 p.m.
Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Phenotypes
Renal
Phenotypes for gene: FLCN were changed from Renal carcinoma; Parotid oncocytomas; Neural tissue tumors; Lipomas; Angiolipomas to Birt-Hogg-Dube syndrome, OMIM:135150; Renal carcinoma, MONDO:0005206
Publications for gene: FLCN were set to PMID: 27899189
Gene: flcn has been classified as Green List (High Evidence).
Source Expert List was added to FLCN. Rating Changed from No List (delete) to Red List (low evidence)
gene: FLCN was added gene: FLCN was added to Inherited renal cancer. Sources: UKGTN Mode of inheritance for gene: FLCN was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted Publications for gene: FLCN were set to PMID: 27899189 Phenotypes for gene: FLCN were set to Renal carcinoma; Parotid oncocytomas; Neural tissue tumors; Lipomas; Angiolipomas Penetrance for gene: FLCN were set to Complete Review for gene: FLCN was set to GREEN gene: FLCN was marked as current diagnostic