Inherited renal cancer
Gene: METComment on phenotypes: This gene is also associated with ?Deafness, autosomal recessive 97 (MIM# 616705); {Osteofibrous dysplasia, susceptibility to} (MIM# 607278); Hepatocellular carcinoma, childhood type, somatic (MIM# 114550)Created: 8 Mar 2021, 1:10 p.m. | Last Modified: 8 Mar 2021, 1:10 p.m.
Panel Version: 1.9
As discussed in the GMS Inherited Cancer Specialist Test Group webex call 31st Jan 2019: The Specialist Test Group agreed that there is enough evidence to rate this gene green.Created: 31 Jul 2019, 12:50 p.m. | Last Modified: 31 Jul 2019, 12:50 p.m.
Panel Version: 0.38
Sources: UKGTNCreated: 28 Dec 2018, 9:33 a.m.
Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Phenotypes
hereditary papillary renal carcinoma with type 1 papillary tumors
Publications
Variants in this GENE are reported as part of current diagnostic practice
Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Phenotypes
Renal
Mode of pathogenicity
Loss-of-function variants (as defined in pop up message) DO NOT cause this phenotype - please provide details in the comments
Comment on list classification: Details checked against the Gene List for Reporting Germline Findings in Cancer Patients Version 1.5 document, for renal tumour type.Created: 26 Jul 2017, 12:14 p.m.
Comment on mode of pathogenicity: Activating variants.Created: 19 Jul 2017, 3:49 p.m.
Phenotypes for gene: MET were changed from hereditary papillary renal carcinoma with type 1 papillary tumors to Renal cell carcinoma, papillary, 1, familial and somatic, OMIM:605074; Papillary renal cell carcinoma, MONDO:0017884
Publications for gene: MET were set to PMID: 27899189
Gene: met has been classified as Green List (High Evidence).
Source Expert List was added to MET. Rating Changed from No List (delete) to Red List (low evidence)
gene: MET was added gene: MET was added to Inherited renal cancer. Sources: UKGTN Mode of inheritance for gene: MET was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted Publications for gene: MET were set to PMID: 27899189 Phenotypes for gene: MET were set to hereditary papillary renal carcinoma with type 1 papillary tumors Penetrance for gene: MET were set to Incomplete Review for gene: MET was set to GREEN gene: MET was marked as current diagnostic