Inherited renal cancer
Gene: PTENComment on list classification: PTEN has been changed from red to amber based on a comment by Shazia Mahamdallie (email communication, October 11th 2019) who notes that "amber status might be more appropriate, i.e. evidence of association but not significant".Created: 14 Oct 2019, 12:52 p.m. | Last Modified: 14 Oct 2019, 12:52 p.m.
Panel Version: 0.41
Comment on list classification: PTEN has been demoted from green to red as it was decided that it does not contribute significantly to inherited renal cancer susceptibility.Created: 12 Sep 2019, 12:56 p.m. | Last Modified: 12 Sep 2019, 12:56 p.m.
Panel Version: 0.39
As discussed in the GMS Inherited Cancer Specialist Test Group webex call 31st Jan 2019: The Specialist Test Group agreed that there is enough evidence to rate this gene green.Created: 31 Jul 2019, 12:50 p.m. | Last Modified: 31 Jul 2019, 12:50 p.m.
Panel Version: 0.38
Sources: UKGTNCreated: 28 Dec 2018, 10:58 a.m.
Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Variants in this GENE are reported as part of current diagnostic practice
Comment on list classification: Details checked against the Gene List for Reporting Germline Findings in Cancer Patients Version 1.5 document, for renal tumour type.Created: 26 Jul 2017, 12:15 p.m.
Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Phenotypes
Breast; Colorectal; Endometrial Carcinoma; Renal
Phenotypes for gene: PTEN were changed from to Renal cell carcinoma (disease), MONDO:0005086
Gene: pten has been classified as Amber List (Moderate Evidence).
Gene: pten has been classified as Red List (Low Evidence).
Gene: pten has been classified as Green List (High Evidence).
Source Expert List was added to PTEN. Rating Changed from No List (delete) to Red List (low evidence)
gene: PTEN was added gene: PTEN was added to Inherited renal cancer. Sources: UKGTN Mode of inheritance for gene: PTEN was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted Review for gene: PTEN was set to GREEN gene: PTEN was marked as current diagnostic