Adult solid tumours cancer susceptibility

Gene: ACD

Amber List (moderate evidence)

ACD (ACD, shelterin complex subunit and telomerase recruitment factor)
EnsemblGeneIds (GRCh38): ENSG00000102977
EnsemblGeneIds (GRCh37): ENSG00000102977
OMIM: 609377, Gene2Phenotype
ACD is in 11 panels

1 review

Ivone Leong (Genomics England Curator)

I don't know

As discussed at the Genomics Cancer Panel Workshop, 16th July 2019: the group agreed that Dyskeratosis congenita associated genes associated with cancer will be included in this panel; however, there does not appear to be enough evidence to change to green status. There are only 2 unrelated cases of patients with DC who have variants in ACD. Both cases did not document any signs of cancer.
Created: 2 Aug 2019, 12:34 p.m. | Last Modified: 2 Aug 2019, 12:34 p.m.
Panel Version: 1.5


History Filter Activity

2 Aug 2019, Gel status: 2

Created, Added New Source, Set mode of inheritance, Set publications, Set Phenotypes

Ivone Leong (Genomics England Curator)

gene: ACD was added gene: ACD was added to Adult solid tumours cancer susceptibility. Sources: NHS GMS,Expert Review Amber Mode of inheritance for gene: ACD was set to BOTH monoallelic and biallelic, autosomal or pseudoautosomal Publications for gene: ACD were set to 25233904; 25205116 Phenotypes for gene: ACD were set to 616553 ?Dyskeratosis congenita 6 and 7