Adult solid tumours cancer susceptibilityGene: BRCA1
Comment on mode of inheritance: Changed from monoallelic to 'both' monoallelic and biallelic, due to feedback from Lara Hawkes and Clare Turnbull (Cancer Clinical Team, Genomics England); biallelic variants in this gene cause Fanconi anemia, complementation group S, whereas monoallelic variants confer susceptibility to Breast-ovarian cancer, familial, 1.
Created: 20 Aug 2018, 11:53 a.m.
Tumor Suppressor. Biallelic phenotype.
Created: 5 Jul 2017, 12:19 p.m.
Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Hereditary Breast and Ovarian Cancer
Clare Turnbull: Tumor Suppressor. Biallelic ph
Mode of inheritance for gene: BRCA1 was changed from MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown to BOTH monoallelic and biallelic, autosomal or pseudoautosomal
BRCA1 was added to Adult solid tumourspanel. Source: Expert Review Green
BRCA1 was created by ellenmcdonagh
BRCA1 was added to Adult solid tumourspanel. Sources: Expert list