Adult solid tumours cancer susceptibility

Gene: CDKN1B

Green List (high evidence)

CDKN1B (cyclin dependent kinase inhibitor 1B)
EnsemblGeneIds (GRCh38): ENSG00000111276
EnsemblGeneIds (GRCh37): ENSG00000111276
OMIM: 600778, Gene2Phenotype
CDKN1B is in 11 panels

2 reviews

Ellen McDonagh (Genomics England Curator)

This gene was reviewed by Lara Hawkes and Clare Turnbull (Cancer Clinical Team, Genomics England) and there are no changes to make.
20 Aug 2018, 11:54 a.m.
Comment on mode of inheritance: Changed to monoallelic after feedback from Clare Turnbull.
27 Jul 2017, 11:04 a.m.

Clare Turnbull (Queen Mary University London)

Green List (high evidence)

Tumor Suppressor.
5 Jul 2017, 12:19 p.m.

Mode of inheritance
BOTH monoallelic and biallelic, autosomal or pseudoautosomal

Phenotypes
Thyroid cancer; Pituitary adenoma

History Filter Activity

7 Sep 2018, Gel status: 3

Panel promoted to version 1.0

Louise Daugherty (Genomics England Curator)

Clare Turnbull: Tumor Suppressor.

27 Jul 2017, Gel status: 4

Set Mode of Inheritance

Ellen McDonagh (Genomics England Curator)

Mode of inheritance for CDKN1B was changed to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

5 Jul 2017, Gel status: 4

Added New Source

Ellen McDonagh (Genomics England Curator)

CDKN1B was added to Adult solid tumourspanel. Source: Expert Review Green

5 Jul 2017, Gel status: 0

Added New Source

Ellen McDonagh (Genomics England Curator)

CDKN1B was added to Adult solid tumourspanel. Sources: Expert list

5 Jul 2017, Gel status: 0

Created

Ellen McDonagh (Genomics England Curator)

CDKN1B was created by ellenmcdonagh