Adult solid tumours cancer susceptibilityGene: VHL
Including in the 'phenotypes' subsection the VHL syndrome, a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign neoplasms, most frequently retinal, cerebellar, and spinal hemangioblastoma, renal cell carcinoma (RCC), pheochromocytoma, and pancreatic tumors.
Created: 6 Aug 2019, 7:40 p.m. | Last Modified: 6 Aug 2019, 7:40 p.m.
Panel Version: 1.6
VON HIPPEL-LINDAU (VHL) SYNDROME, OMIM 193300
As discussed at the Genomics Cancer Panel Workshop, 16th July 2019: the group agreed that there is enough evidence to rate this gene green
Created: 2 Aug 2019, 12:34 p.m. | Last Modified: 2 Aug 2019, 12:34 p.m.
Panel Version: 1.5
Created: 5 Jul 2017, 12:19 p.m.
Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Familial Paraganglioma and Pheochromocytoma
Phenotypes for gene: VHL were changed from Familial Paraganglioma and Pheochromocytoma to Familial Paraganglioma and Pheochromocytoma; VON HIPPEL-LINDAU (VHL) SYNDROME, 193300
Source NHS GMS was added to VHL.
Clare Turnbull: Tumor Suppressor.
VHL was added to Adult solid tumourspanel. Source: Expert Review Green
VHL was created by ellenmcdonagh
VHL was added to Adult solid tumourspanel. Sources: Expert list