Adult solid tumours cancer susceptibility

Gene: CHEK2

Amber List (moderate evidence)

CHEK2 (checkpoint kinase 2)
EnsemblGeneIds (GRCh38): ENSG00000183765
EnsemblGeneIds (GRCh37): ENSG00000183765
OMIM: 604373, Gene2Phenotype
CHEK2 is in 8 panels

2 reviews

Ellen McDonagh (Genomics England Curator)

Comment on list classification: Demoted this gene from Green to Amber due to feedback from Lara Hawkes and Clare Turnbull (Cancer Clinical Team, Genomics England), that this gene confers a moderate risk.
Created: 20 Aug 2018, 11:54 a.m.

Clare Turnbull (Queen Mary University London)

Green List (high evidence)

Tumor Suppressor. Biallelic phenotype.
Created: 5 Jul 2017, 12:19 p.m.

Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Phenotypes
Breast cancer

Details

Mode of Inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Sources
  • NHS GMS
  • Expert Review Amber
  • Expert list
Phenotypes
  • Breast cancer
OMIM
604373
Clinvar variants
Variants in CHEK2
Penetrance
Complete
Panels with this gene

History Filter Activity

2 Aug 2019, Gel status: 2

Added New Source

Ivone Leong (Genomics England Curator)

Source NHS GMS was added to CHEK2.

7 Sep 2018, Gel status: 2

Panel promoted to version 1.0

Louise Daugherty (Genomics England Curator)

Clare Turnbull: Tumor Suppressor. Biallelic ph

20 Aug 2018, Gel status: 2

Entity classified by Genomics England curator

Ellen McDonagh (Genomics England Curator)

Gene: chek2 has been classified as Amber List (Moderate Evidence).

5 Jul 2017, Gel status: 4

Added New Source

Ellen McDonagh (Genomics England Curator)

CHEK2 was added to Adult solid tumourspanel. Source: Expert Review Green

5 Jul 2017, Gel status: 0

Added New Source

Ellen McDonagh (Genomics England Curator)

CHEK2 was added to Adult solid tumourspanel. Sources: Expert list

5 Jul 2017, Gel status: 0

Created

Ellen McDonagh (Genomics England Curator)

CHEK2 was created by ellenmcdonagh