Adult solid tumours cancer susceptibility
Gene: CBL

CBL (Cbl proto-oncogene)
EnsemblGeneIds (GRCh38): ENSG00000110395
EnsemblGeneIds (GRCh37): ENSG00000110395
OMIM: 165360, Gene2Phenotype
CBL is in 18 panels

2 reviews

Ivone Leong (Genomics England Curator)

Green List (high evidence)

As discussed at the Genomics Cancer Panel Workshop, 16th July 2019: the group agreed that RASopathy associated genes associated with cancer will be included in this panel and that there is enough evidence to rate this gene green.
Created: 2 Aug 2019, 12:34 p.m. | Last Modified: 2 Aug 2019, 12:34 p.m.

Panel Version: 1.5

Created: 2 Aug 2019, 12:34 p.m.
Last Modified: 2 Aug 2019, 12:34 p.m.
Panel version: 1.5

Anna de Burca (Oxford University Hospitals NHS Foundation Trust)

Green List (high evidence)

Predisposition to cancer
Created: 2 Aug 2019, 12:34 p.m. | Last Modified: 2 Aug 2019, 12:34 p.m.

Panel Version: 1.5

Publications

23875798

Created: 2 Aug 2019, 12:34 p.m.
Last Modified: 2 Aug 2019, 12:34 p.m.
Panel version: 1.5

Details

Mode of Inheritance

MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Sources

NHS GMS
Expert Review Green

Phenotypes

Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia 613563

OMIM

165360

Clinvar variants

Variants in CBL

Penetrance

None

Publications

23875798

Panels with this gene

History Filter Activity

2 Aug 2019, Gel status: 3

Created, Added New Source, Set mode of inheritance, Set publications, Set Phenotypes

Ivone Leong (Genomics England Curator)

gene: CBL was added gene: CBL was added to Adult solid tumours cancer susceptibility. Sources: Expert Review Green,NHS GMS Mode of inheritance for gene: CBL was set to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown Publications for gene: CBL were set to 23875798 Phenotypes for gene: CBL were set to Noonan syndrome-like disorder with or without juvenile myelomonocytic leukemia 613563

Adult solid tumours cancer susceptibility Gene: CBL