Adult solid tumours cancer susceptibility
Gene: MAP2K2

MAP2K2 (mitogen-activated protein kinase kinase 2)
EnsemblGeneIds (GRCh38): ENSG00000126934
EnsemblGeneIds (GRCh37): ENSG00000126934
OMIM: 601263, Gene2Phenotype
MAP2K2 is in 17 panels

2 reviews

Ivone Leong (Genomics England Curator)

I don't know

As discussed at the Genomics Cancer Panel Workshop, 16th July 2019: the group agreed that RASopathy associated genes associated with cancer will be included in this panel; however, there it is unclear whether this gene predisposes patients to cancer so therefore this has been rated amber.
Created: 2 Aug 2019, 12:34 p.m. | Last Modified: 2 Aug 2019, 12:34 p.m.

Panel Version: 1.5

Created: 2 Aug 2019, 12:34 p.m.
Last Modified: 2 Aug 2019, 12:34 p.m.
Panel version: 1.5

Anna de Burca (Oxford University Hospitals NHS Foundation Trust)

I don't know

Unclear predisposition to cancer
Created: 2 Aug 2019, 12:34 p.m. | Last Modified: 2 Aug 2019, 12:34 p.m.

Panel Version: 1.5

Publications

23875798

Created: 2 Aug 2019, 12:34 p.m.
Last Modified: 2 Aug 2019, 12:34 p.m.
Panel version: 1.5

Details

Mode of Inheritance

MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Sources

Expert Review Amber
NHS GMS

Phenotypes

Cardiofaciocutaneous syndrome 4 615280

OMIM

601263

Clinvar variants

Variants in MAP2K2

Penetrance

None

Publications

23875798

Panels with this gene

History Filter Activity

2 Aug 2019, Gel status: 2

Created, Added New Source, Set mode of inheritance, Set publications, Set Phenotypes

Ivone Leong (Genomics England Curator)

gene: MAP2K2 was added gene: MAP2K2 was added to Adult solid tumours cancer susceptibility. Sources: NHS GMS,Expert Review Amber Mode of inheritance for gene: MAP2K2 was set to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown Publications for gene: MAP2K2 were set to 23875798 Phenotypes for gene: MAP2K2 were set to Cardiofaciocutaneous syndrome 4 615280

Adult solid tumours cancer susceptibility Gene: MAP2K2