Adult solid tumours cancer susceptibility
Gene: PALB2EnsemblGeneIds (GRCh38): ENSG00000083093
EnsemblGeneIds (GRCh37): ENSG00000083093
OMIM: 610355, Gene2Phenotype
PALB2 is in 26 panels
2 reviews
Ivone Leong (Genomics England Curator)
As discussed at the Genomics Cancer Panel Workshop, 16th July 2019: the group agreed that there is enough evidence to rate this gene greenCreated: 2 Aug 2019, 12:34 p.m. | Last Modified: 2 Aug 2019, 12:34 p.m.
Panel Version: 1.5
Clare Turnbull (Queen Mary University London)
Tumor Suppressor. Biallelic phenotype.Created: 5 Jul 2017, 12:19 p.m.
Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Phenotypes
breast, pancreas
Details
- Mode of Inheritance
- MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
- Sources
-
- NHS GMS
- Expert Review Green
- Expert list
- Phenotypes
-
- Fanconi anemia, complementation group N, 610832
- {Breast cancer, susceptibility to}, 114480
- {Pancreatic cancer, susceptibility to, 3}, 613348
- High Risk Breast Cancer
- Breast and Ovarian Cancer
- OMIM
- 610355
- Clinvar variants
- Variants in PALB2
- Penetrance
- Complete
- Publications
- Panels with this gene
-
- Inherited ovarian cancer (without breast cancer)
- Fetal anomalies
- Severe microcephaly
- Childhood solid tumours cancer susceptibility
- Radial dysplasia
- Intellectual disability
- Familial breast cancer
- Inherited breast cancer and ovarian cancer
- Cytopenias and congenital anaemias
- Limb disorders
- Inherited prostate cancer
- Familial Tumours Syndromes of the central & peripheral Nervous system
- DDG2P
- Haematological malignancies cancer susceptibility
- Inherited pancreatic cancer
- Pigmentary skin disorders
- Monogenic short stature
- COVID-19 research
- Neurofibromatosis Type 1
- Haematological malignancies for rare disease
- Adult solid tumours for rare disease
- Breast cancer pertinent cancer susceptibility
- Familial prostate cancer
- Confirmed Fanconi anaemia or Bloom syndrome
- Childhood solid tumours
- Adult solid tumours cancer susceptibility
History Filter Activity
Set publications
Arina Puzriakova (Genomics England Curator)Publications for gene: PALB2 were set to
Set Phenotypes
Arina Puzriakova (Genomics England Curator)Phenotypes for gene: PALB2 were changed from breast, pancreas to Fanconi anemia, complementation group N, 610832; {Breast cancer, susceptibility to}, 114480; {Pancreatic cancer, susceptibility to, 3}, 613348; High Risk Breast Cancer; Breast and Ovarian Cancer
Added New Source
Ivone Leong (Genomics England Curator)Source NHS GMS was added to PALB2.
Panel promoted to version 1.0
Louise Daugherty (Genomics England Curator)Clare Turnbull: Tumor Suppressor. Biallelic ph
Added New Source
Ellen McDonagh (Genomics England Curator)PALB2 was added to Adult solid tumourspanel. Source: Expert Review Green
Created
Ellen McDonagh (Genomics England Curator)PALB2 was created by ellenmcdonagh
Added New Source
Ellen McDonagh (Genomics England Curator)PALB2 was added to Adult solid tumourspanel. Sources: Expert list