Adult solid tumours cancer susceptibility
Gene: SPRED1

SPRED1 (sprouty related EVH1 domain containing 1)
EnsemblGeneIds (GRCh38): ENSG00000166068
EnsemblGeneIds (GRCh37): ENSG00000166068
OMIM: 609291, Gene2Phenotype
SPRED1 is in 13 panels

1 review

Ivone Leong (Genomics England Curator)

Red List (low evidence)

As discussed at the Genomics Cancer Panel Workshop, 16th July 2019: the group agreed that RASopathy associated genes associated with cancer will be included in this panel; however, this gene does not appear to predispose patients to cancer so therefore this has been rated red.
Created: 2 Aug 2019, 12:34 p.m. | Last Modified: 2 Aug 2019, 12:34 p.m.

Panel Version: 1.5

No apparent predisposition to cancer
Created: 2 Aug 2019, 12:34 p.m. | Last Modified: 2 Aug 2019, 12:34 p.m.

Panel Version: 1.5

Publications

23875798

Created: 2 Aug 2019, 12:34 p.m.
Last Modified: 2 Aug 2019, 12:34 p.m.
Panel version: 1.5

Details

Mode of Inheritance

MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Sources

NHS GMS

Phenotypes

Legius syndrome 611431

OMIM

609291

Clinvar variants

Variants in SPRED1

Penetrance

None

Publications

23875798

Panels with this gene

History Filter Activity

2 Aug 2019, Gel status: 1

Created, Added New Source, Set mode of inheritance, Set publications, Set Phenotypes

Ivone Leong (Genomics England Curator)

gene: SPRED1 was added gene: SPRED1 was added to Adult solid tumours cancer susceptibility. Sources: NHS GMS Mode of inheritance for gene: SPRED1 was set to MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown Publications for gene: SPRED1 were set to 23875798 Phenotypes for gene: SPRED1 were set to Legius syndrome 611431

Adult solid tumours cancer susceptibility Gene: SPRED1