This Panel is marked as Retired
Multiple Tumours
Gene: FLCN
FLCN (folliculin)
EnsemblGeneIds (GRCh38): ENSG00000154803
EnsemblGeneIds (GRCh37): ENSG00000154803
OMIM: 607273, Gene2Phenotype
FLCN is in 12 panels
EnsemblGeneIds (GRCh38): ENSG00000154803
EnsemblGeneIds (GRCh37): ENSG00000154803
OMIM: 607273, Gene2Phenotype
FLCN is in 12 panels
1 review
Ellen McDonagh (Genomics England Curator)
Comment on list classification: Promoted from red to green, as this gene is reported as part of germline findings in the Cancer Programme, for Renal cancer.Created: 18 Apr 2017, 9:38 a.m.
Information from TruSight panel: Pathogenic Mutations are Inactivating.Created: 5 Feb 2016, 11:46 a.m.
Details
- Mode of Inheritance
- MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
- Sources
-
- Expert Review Green
- TruSight Cancer Panel (Illumina)
- Phenotypes
-
- Birt-Hogg-Dube Syndrome
- Renal cell cancer, oncocytoma
- OMIM
- 607273
- Clinvar variants
- Variants in FLCN
- Penetrance
- Complete
- Panels with this gene
-
- Renal cancer pertinent cancer susceptibility
- Thoracic aortic aneurysm or dissection (GMS)
- Multiple monogenic benign skin tumours
- Adult solid tumours cancer susceptibility
- Familial pulmonary fibrosis
- Thoracic aortic aneurysm or dissection
- Inherited renal cancer
- Cystic kidney disease
- Ehlers Danlos syndrome with a likely monogenic cause
- Fetal anomalies
- Pneumothorax - familial
- Adult solid tumours for rare disease
History Filter Activity
18 Apr 2017, Gel status: 4
Gene classified by Genomics England curator
Ellen McDonagh (Genomics England Curator)This gene has been classified as Green List (High Evidence).
18 Apr 2017, Gel status: 4
Set Mode of Inheritance
Ellen McDonagh (Genomics England Curator)Mode of inheritance for FLCN was changed to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
18 Apr 2017, Gel status: 4
Gene classified by Genomics England curator
Ellen McDonagh (Genomics England Curator)This gene has been classified as Green List (High Evidence).
5 Feb 2016, Gel status: 0
Created
Ellen McDonagh (Genomics England Curator)FLCN was created by ellenmcdonagh
5 Feb 2016, Gel status: 0
Added New Source
Ellen McDonagh (Genomics England Curator)FLCN was added to Multiple Tumourspanel. Sources: TruSight Cancer Panel (Illumina)