This Panel is marked as Internal
Tumour predisposition - adult onset
Gene: ATM
ATM (ATM serine/threonine kinase)
EnsemblGeneIds (GRCh38): ENSG00000149311
EnsemblGeneIds (GRCh37): ENSG00000149311
OMIM: 607585, Gene2Phenotype
ATM is in 32 panels
EnsemblGeneIds (GRCh38): ENSG00000149311
EnsemblGeneIds (GRCh37): ENSG00000149311
OMIM: 607585, Gene2Phenotype
ATM is in 32 panels
0 reviews
Details
- Mode of Inheritance
- BIALLELIC, autosomal or pseudoautosomal
- Sources
-
- Expert Review Green
- Familial Tumours Syndromes of the central & peripheral Nervous system (Version 1.8)
- Adult solid tumours for rare disease (Version 1.21)
- Phenotypes
-
- Brain, CNS, and PNS Cancer
- Ataxia Telangiectasia
- OMIM
- 607585
- Clinvar variants
- Variants in ATM
- Penetrance
- None
- Panels with this gene
-
- Familial breast cancer
- Intellectual disability
- Haematological malignancies cancer susceptibility
- Brain cancer pertinent cancer susceptibility
- Hereditary ataxia with onset in adulthood
- DDG2P
- Primary ovarian insufficiency
- Fetal anomalies
- Haematological malignancies for rare disease
- Adult onset neurodegenerative disorder
- Inherited breast cancer and ovarian cancer
- Inherited prostate cancer
- Childhood onset dystonia, chorea or related movement disorder
- Ataxia telangiectasia - mutation testing
- Inherited pancreatic cancer
- Hereditary neuropathy
- Adult onset dystonia, chorea or related movement disorder
- Ataxia and cerebellar anomalies - narrow panel
- Childhood solid tumours cancer susceptibility
- Vascular skin disorders
- Familial Tumours Syndromes of the central & peripheral Nervous system
- COVID-19 research
- Inherited ovarian cancer (without breast cancer)
- Hereditary ataxia
- Adult solid tumours for rare disease
- Hereditary neuropathy or pain disorder
- Sarcoma susceptibility
- Early onset dystonia
- Adult solid tumours cancer susceptibility
- Childhood solid tumours
- Primary immunodeficiency or monogenic inflammatory bowel disease
- Hereditary haemorrhagic telangiectasia
History Filter Activity
31 Jan 2019, Gel status: 4
Panel promoted to version 1.0
Rebecca Foulger (Genomics England curator)Panel checked against two component panels (Adult solid tumours for rare disease v1.21 and Familial Tumours Syndromes of the central & peripheral Nervous system v1.8) and promoted to Version 1.0.
17 Dec 2018, Gel status: 4
Set Phenotypes
Rebecca Foulger (Genomics England curator)Added phenotypes Brain, CNS, and PNS Cancer for gene: ATM
17 Dec 2018, Gel status: 4
Created, Added New Source, Set mode of inheritance, Set Phenotypes
Rebecca Foulger (Genomics England curator)gene: ATM was added gene: ATM was added to Tumour predisposition - adult onset. Sources: Adult solid tumours for rare disease (Version 1.21),Familial Tumours Syndromes of the central & peripheral Nervous system (Version 1.8),Expert Review Green Mode of inheritance for gene: ATM was set to BIALLELIC, autosomal or pseudoautosomal Phenotypes for gene: ATM were set to Ataxia Telangiectasia