Inherited renal cancer
Gene: METEnsemblGeneIds (GRCh38): ENSG00000105976
EnsemblGeneIds (GRCh37): ENSG00000105976
OMIM: 164860, Gene2Phenotype
MET is in 10 panels
6 reviews
Arina Puzriakova (Genomics England Curator)
Comment on phenotypes: This gene is also associated with ?Deafness, autosomal recessive 97 (MIM# 616705); {Osteofibrous dysplasia, susceptibility to} (MIM# 607278); Hepatocellular carcinoma, childhood type, somatic (MIM# 114550)Created: 8 Mar 2021, 1:10 p.m. | Last Modified: 8 Mar 2021, 1:10 p.m.
Panel Version: 1.9
Ivone Leong (Genomics England Curator)
As discussed in the GMS Inherited Cancer Specialist Test Group webex call 31st Jan 2019: The Specialist Test Group agreed that there is enough evidence to rate this gene green.Created: 31 Jul 2019, 12:50 p.m. | Last Modified: 31 Jul 2019, 12:50 p.m.
Panel Version: 0.38
Lara Hawkes (Genomics England)
Rachel Robinson (Leeds Genetics Laboratory)
Sources: UKGTNCreated: 28 Dec 2018, 9:33 a.m.
Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Phenotypes
hereditary papillary renal carcinoma with type 1 papillary tumors
Publications
- PMID: 27899189
Variants in this GENE are reported as part of current diagnostic practice
Clare Turnbull (Queen Mary University London)
Mode of inheritance
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Phenotypes
Renal
Mode of pathogenicity
Loss-of-function variants (as defined in pop up message) DO NOT cause this phenotype - please provide details in the comments
Ellen McDonagh (Genomics England Curator)
Comment on list classification: Details checked against the Gene List for Reporting Germline Findings in Cancer Patients Version 1.5 document, for renal tumour type.Created: 26 Jul 2017, 12:14 p.m.
Comment on mode of pathogenicity: Activating variants.Created: 19 Jul 2017, 3:49 p.m.
Details
- Mode of Inheritance
- MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
- Sources
-
- Expert Review Green
- Expert List
- Phenotypes
-
- Renal cell carcinoma, papillary, 1, familial and somatic, OMIM:605074
- Papillary renal cell carcinoma, MONDO:0017884
- OMIM
- 164860
- Clinvar variants
- Variants in MET
- Penetrance
- Incomplete
- Publications
- Panels with this gene
History Filter Activity
Set Phenotypes
Arina Puzriakova (Genomics England Curator)Phenotypes for gene: MET were changed from hereditary papillary renal carcinoma with type 1 papillary tumors to Renal cell carcinoma, papillary, 1, familial and somatic, OMIM:605074; Papillary renal cell carcinoma, MONDO:0017884
Set publications
Rebecca Foulger (Genomics England curator)Publications for gene: MET were set to PMID: 27899189
Entity classified by Genomics England curator
Ivone Leong (Genomics England Curator)Gene: met has been classified as Green List (High Evidence).
Added New Source, Status Update
Ivone Leong (Genomics England Curator)Source Expert List was added to MET. Rating Changed from No List (delete) to Red List (low evidence)
Created, Added New Source, Set mode of inheritance, Set publications, Set Phenotypes, Set penetrance
Rachel Robinson (Leeds Genetics Laboratory)gene: MET was added gene: MET was added to Inherited renal cancer. Sources: UKGTN Mode of inheritance for gene: MET was set to MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted Publications for gene: MET were set to PMID: 27899189 Phenotypes for gene: MET were set to hereditary papillary renal carcinoma with type 1 papillary tumors Penetrance for gene: MET were set to Incomplete Review for gene: MET was set to GREEN gene: MET was marked as current diagnostic